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Studies Of DNA Mismatch Repair

Studies Of DNA Mismatch Repair
DNA错配修复的研究
批准号：
8734109
负责人：
THOMAS A KUNKEL
金额：
$171.83万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8734109
关键词：
ApoptosisBiochemistryBiological ProcessCell SurvivalDNADNA DamageDNA Double Strand BreakDNA Polymerase IDNA SequenceDNA biosynthesisDegenerative DisorderDiseaseEukaryotic CellExodeoxyribonuclease IGenesGeneticGenetic RecombinationGenome StabilityGoalsHealthHumanImmunoglobulin GenesImmunoglobulin Somatic HypermutationInfertilityInheritedLeadMalignant NeoplasmsMeiotic RecombinationMismatch RepairMusMutationPathway interactionsPlayProteinsReplication ErrorRibonucleotidesRoleSignal TransductionTrinucleotide Repeatsbiological adaptation to stresspreventprotein functionrepairedresponse

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中文摘要
翻译
今年，我们首次对领先和滞后链复制错误的MMR效率进行了全面比较。我们证明核酸外切酶1优先修复由DNA聚合酶α产生的错配。我们提供了强有力的证据，证明核糖核苷酸是前导链复制错误的错配修复信号。最后，我们与温弗里德·埃德尔曼合作进行的一项研究表明，小鼠Exo1编码结构和催化功能，在几个基本的生物过程中发挥不同的作用。
英文摘要
This year, we provided the first comprehensive comparison of the efficiency of MMR of leading and lagging strand replication errors. We demonstrated that exonuclease 1 preferentially repairs mismatches generated by DNA polymerase alpha. We provided strong evidence that ribonucleotides are signals for mismatch repair of leading strand replication errors. Finally, we collaborated with Winfried Edelmann on a study indicating that mouse Exo1 encodes both structural and catalytic functions that play distinct roles in several essential biological processes.
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DNA REPLICATION FIDELITY
STUDIES OF DNA MISMATCH REPAIR
DNA Replication Fidelity
Studies Of DNA Mismatch Repair
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