Muscular Dystrophy Center Core Laboratories

明尼苏达大学肌肉萎缩中心（UMN-MDCenter）自成立以来，在肌肉生物学和疾病的基础、临床和转化研究方面的合作不断扩大。MDCenter的成功最近帮助招募了几位杰出的肌肉研究人员到明尼苏达州，利用现有的力量创建了一个独特的多方面的项目，专注于了解肌肉和治疗肌肉疾病。为了最大限度地扩大MDCenter的互动，协作和生产力，我们正在申请NIAMS核心中心支持，具体目标如下：

The University of Minnesota Muscular Dystrophy Center (UMN-MDCenter) has grown in scope and breadth since being organized to improve collaboration in basic, clinical and translational investigation of muscle biology and disease. Success of the MDCenter has recently helped recruit several prominent muscle investigators to Minnesota, capitalizing on existing strength to create what is now a unique multifaceted program focused on understanding muscle and treating muscle disease. To maximize interaction, collaboration and productivity of the expanding MDCenter, we are applying for NIAMS Core Center support with the following specific aims: 1) Core B: To strengthen and increase accessibility of a research core that provides clinical specimens to muscle investigators, and uses the CLIA-certified muscle biopsy laboratory to characterize human and animal muscle with comprehensive histological and immunostaining methods. 2) Core C: To strengthen and expand a repository of murine muscular dystrophy models for muscle investigators, which is coupled with the unique ability of our Center to characterize human and animal muscle force generation at molecular, cellular and whole tissue levels. 3) Core A: To provide administrative support for the research cores, and to establish a pilot and feasibility program for new independent investigators, which will strengthen and extend current MDCenter programs for undergraduate, graduate and post-doctoral trainees. 4) To increase institutional, regional and national awareness of UMN-MDCenter and CCMBM to enhance provision of institutional resources commensurate with the potential of this program.