Improving treatment of non-small cell lung cancer: suppressing cell division cycle associated protein 3 (CDCA3)

肺癌是全球癌症相关死亡的主要原因。该项目将确立抑制分子“细胞分裂周期相关蛋白3”（CDCA 3）在肺癌中的价值。为此，我们将调整动物肺癌模型中CDCA 3的水平，并用化疗和新药CX-4945治疗肿瘤。我们预计，在NSCLC患者中降低CDCA 3水平联合CX-4945和/或化疗将有益于患者结局。

Lung cancer is the leading cause of cancer-related mortality worldwide. This project will establish the worth of suppressing the molecule ‘cell division cycle associated protein 3’ (CDCA3) in lung cancer. To do so, we will adjust the levels of CDCA3 in animal lung cancer models and treat the tumours with chemotherapy and the novel drug CX-4945. We expect that reduced levels of CDCA3 combined with CX-4945 and/or chemotherapy in NSCLC patients will benefit patient outcome.