Administrative Core

项目总结（见说明）： 该方案的主要目标是促进杀微生物剂复方的阴道环配方，以安全地减少艾滋病毒的性传播。整个计划包括3个项目和一个科学核心，并由几个关键的分包合同组成，这些分包合同将使科学团队能够实现其目标。研究者、实验室和临床研究中心之间的相互作用对本计划的成功至关重要。因此，一个组织良好、定义明确的行政结构是使这一奋进取得最大成功的必要条件。行政核心将监督项目的日常管理，并确保所有研究中心的沟通和协调。行政核心成员将与研究者、药学合作者、NIH代表和指定科学顾问小组成员密切合作。该核心的目的是协调该方案的财政和组织方面。核心人员将负责维持和审查预算，并为与研究有关的旅行提供便利。此外，行政人员将负责采购项目1和2研究所需的非人灵长类动物，并监督临床样本在研究中心之间的运输。行政核心工作人员将安排所有研究相关电话会议和年度会议。核心还将为项目总监、项目和核心负责人提供指导，以顺利进行机构间复杂的互动，包括协助分包合同、IRB和临床研究中心提交材料，以及识别和解决意外问题。

PROJECT SUMMARY (See Instructions): The primary objective of this Program is to advance an intravaginal ring formulation of a microbicide combination to safely reduce the sexual transmission of HIV. The overall Program includes 3 Projects and a Scientific Core and is comprised of several critical subcontracts that will enable the scientific team to achieve its goals. The interactions between the investigators, laboratories and clinical research sites are essential to the success of this Program. Consequently, a well-organized, well-defined administrative structure is necessary to optimize the success of this endeavor. The Administrative Core will oversee the day-to-day management of the Program and ensure communication and coordination of all study sites. The members of the Administrative Core will work closely with the investigators, pharmaceutical collaborators, NIH representatives and members of the designated Scientific Advisory Panel. The aims of the Core are to coordinate the fiscal and organizational aspects of the Program. The Core will be responsible for maintaining and reviewing budgets and will facilitate research related travel. In addition, administrative staff will be responsible for the procurement of non-human primates for studies in Projects 1 and 2 as well as overseeing the shipment of clinical samples between the sites. The Administrative Core staff will arrange all study related conference calls and annual meetings. The Core will also provide guidance to the Program Director, Project and Core Leaders for smooth, inter-institutional complex interactions, including assistance with subcontracts, IRB, and Clinical Research Center submissions and identifying and resolving unanticipated problems.