2013 Neurofibromatosis (NF) Conference

描述（由申请人提供）：神经纤维瘤病（NF）会议自1985年以来每年由儿童肿瘤基金会（CTF）组织。NF会议起源于一个名为“NF联盟”的小组的小型研讨会式聚会，致力于克隆神经纤维瘤病的基因，NF会议已经发展成为来自世界各地的350多名NF研究人员和临床医生的聚会。该会议被公认为国际NF研究人员和医生的首要年度聚会。这一增长的主要贡献者是近年来NF研究取得的重大进展，特别是临床试验和药物治疗开发的最新进展。此外，国家 现有技术的基因组方法已经鉴定出NF基因中的突变是许多类型散发性癌症的贡献者。包括Hippo和Ras级联的信号通路与NF有关，现在认识到Ras通路上的基因沿着突变导致一系列疾病，包括NF 1，称为“Ras病”。传统上是一个研究信息交流和建立共识的论坛，近年来，NF会议也是报告神经纤维瘤病临床前治疗管道和神经纤维瘤病临床试验扩展竞技场的主要国际论坛。儿童肿瘤基金会：2013年NF会议PI：Plotkin，Scott，医学博士1

DESCRIPTION (provided by applicant): The Neurofibromatosis (NF) Conference has been organized by the Children's Tumor Foundation (CTF) annually since 1985. With its roots in a small workshop-style gathering of a group called the "NF Consortium" dedicated to cloning the genes underlying the Neurofibromatoses, the NF Conference has grown to a gathering of well over 350 NF researchers and clinicians from around the world. This meeting is recognized as the premier annual gathering of international NF researchers and physicians. Major contributors to this growth are the significant advances made in NF research in recent years and, particularly, recent advances into clinical trials and drug therapy development. In addition, state of-the-art genomic approaches have identified mutations in the NF genes as contributors to numerous types of sporadic cancers. Signaling pathways including the Hippo and Ras cascades are implicated in NF, and it is now recognized that mutations in genes along the Ras pathway result in a set of disorders, including NF1, called the "Rasopathies". Traditionally a forum for research information exchange and consensus building, in recent years the NF Conference is also the principal international forum for reporting on the neurofibromatosis preclinical therapeutic pipeline and the expanding arena of neurofibromatosis clinical trials. Children's Tumor Foundation: 2013 NF Conference PI: Plotkin, Scott, M.D. 1