Optimizing Couple-Oriented Interventions for Chronic Illness

描述（由申请人提供）：大多数患有慢性疾病的成年人已婚或处于亲密关系中，但绝大多数行为干预措施未能解决这种关系的影响或疾病对伴侣的影响。因此，这种干预措施对许多患者不太可能完全有效，甚至可能适得其反。林恩·马蒂尔博士获得K02独立科学家奖（伊萨）的目的是促进以夫妇为导向的慢性病干预措施（CI）的发展，使患者和配偶受益，并为婚姻和健康模式提供信息。该奖项的重点将是美国所有健康问题中最致命和最昂贵的三种慢性疾病：心血管疾病，癌症和糖尿病。Martire博士的职业发展活动将解决设计，测量和分析问题，这些问题对未来CI研究的成功至关重要。该伊萨的研究活动将为有关婚姻和健康的文献增加重要信息，并通过关注家庭环境中发生的短期过程如何影响健康来告知下一代CI。目的#1和2将使用在膝关节骨关节炎和2型糖尿病研究中收集的二元日记数据，检查患有慢性疾病的夫妇的日常过程，以及缓和这些过程的个人和夫妇水平特征。目标3是收集关于夫妻在家中与健康有关的互动的试点观察数据。目标4将把这些和其他项目的发现应用于为夫妇制定适应性的跨疾病干预措施。候选人是唯一准备在这一领域取得重大进展，由于她在晚年慢性疾病，家庭护理，以及干预对病人和照顾者的影响的研究专长。研究和培训活动将由一个顾问团队提供便利，他们是亲密关系，健康，纵向测量和分析，干预开发和生态瞬时干预领域的领先专家。此外，候选人还组建了一个国家工作组，由已建立的研究人员组成，针对本伊萨的三个焦点条件测试CI。

DESCRIPTION (provided by applicant): Most adults who suffer from a chronic illness are married or in an intimate relationship, yet the vast majority of behavioral interventions fail to address this relationship's impact or the effects of illness on the partner. Therefore, such interventions are not likely to be fully effective for many patients, and may even backfire. The purpose of this proposed K02 Independent Scientist Award (ISA) to Dr. Lynn Martire is to advance the development of couple-oriented interventions (CIs) for chronic illness that benefit both patients and spouses and also inform models of marriage and health. The focus of this award will be three chronic conditions that are the most deadly and costly of all health problems in the United States: cardiovascular disease, cancer, and diabetes. Dr. Martire's career development activities will address design, measurement, and analysis issues that are critical for the success of future CI research. The research activities of this ISA will add critical information to the literature on marriage and health, and inform the next generation of CIs, by focusing on how short-term processes that occur in the home environment affect health. Aims #1 and 2 will examine daily processes in couples living with chronic illness, as well as individual and couple-level characteristics that moderate these processes, using dyadic diary data collected in studies of knee osteoarthritis and Type 2 diabetes. Aim #3 is to collect pilot observational data on couples' health-related interactions in the home. Aim #4 will apply findings from these and other projects to the development of an adaptive, cross-disease intervention for couples. The Candidate is uniquely poised to make significant advances in this area due to her research expertise in late-life chronic illness, family caregiving, and the effects of intervention on both patient and caregiver. Research and training activities will be facilitated by a team of Consultants who are leading experts in the areas of intimate relationships, health, longitudinal measurement and analysis, intervention development, and ecological momentary intervention. In addition, the Candidate has assembled a National Working Group of established researchers testing CIs for the three focal conditions of this ISA.