Incorporating genomics into breast cancer management

这项研究将调查基因组测序在晚期和早期乳腺癌中的应用。我们将描述在转移环境中从两种不同治疗中受益的患者的基因特征。我们将使用循环肿瘤DNA分析来监测和确定经初步治疗明显治愈的患者的微小残留病(MRD)的遗传学特征。这将确定潜在的治疗靶点，以防止MRD进展为转移性疾病。

This study will investigate use of genomic sequencing in advanced and early breast cancer. We will characterise genetic characteristics of patients who benefit from two different therapies in the metastatic setting. We will use circulating tumour DNA analysis to monitor for and genetically characterise minimal residual disease (MRD) in patients apparently cured by initial therapy. This will thus identify potential therapeutic targets for preventing MRD progressing to metastatic disease.