Increased airway smooth muscle mass as an independent determinant of asthma pathogenesis and severity

哮喘是社区的主要健康负担。这种疾病最常见的形式是过敏性哮喘，人们认为过敏性炎症会导致相关的气道异常，包括气道平滑肌（ASM）质量增加。本研究验证了一个新的假设，即气道异常和过敏有不同的起源，但共同产生过敏性哮喘，并且ASM最多的个体发展为临床严重哮喘。

Asthma is a major health burden to the community. The most common form of the disease is allergic asthma and it is thought that allergic inflammation drives associated airway abnormalities including increased airway smooth muscle (ASM) mass. This study tests a new hypothesis that airway abnormalities and allergy have separate origins but combine to produce allergic asthma, and it’s the individuals with the greatest amount of ASM who develop clinically severe asthma.