Center for Research on the Ethical, Legal and Social Implications of Psychiatric

描述(由申请人提供)：本申请建议在哥伦比亚大学医学中心(CUMC)建立精神病学、神经学和行为遗传学(PNB)遗传学的伦理、法律和社会影响研究中心。自2010年4月以来，我们一直在P20发展中心赠款下获得资金，以创建基础设施并开始发展这样一个中心。PNB遗传学面临着特别的伦理、法律和社会挑战，因为许多PNB疾病和特征的高度污名化的性质；PNB疾病和特征的遗传倾向对行为责任感的潜在影响；以及遗传倾向和环境影响之间的复杂相互作用，这些因素决定了许多PNB疾病的开始和过程，使得许多PNB基因数据的含义本质上是模糊的。我们的新中心将促进对PNB遗传学背景下出现的一系列问题的深思熟虑，并开发创新的方法来解决这些问题。具体地说，我们将开展一项重点研究计划，探索PNB基因信息在个人、熟悉和社会层面的影响，考虑其对耻辱和自我形象、责任归属和对模棱两可的反应的影响，并系统地考虑我们发现的更广泛的规范和政策影响。为了最大限度地发挥我们研究的价值，我们将建立强有力的机制，利用其他专家和关键利益攸关方群体的参与，将我们研究的经验和规范成果转化为政策和实践建议。着眼于ELSI研究的未来，我们将开发一个多学科的博士后培训计划，重点培养ELSI研究的未来领导者，创造一个促进跨学科学习和研究的环境，并吸引优秀的导师和教师。总而言之，我们将在现有优势和成就的基础上建立一个结构，以加强跨学科合作，促进创新研究的进行，并促进教职员工和受训人员的智力增长。

DESCRIPTION (provided by applicant): This application proposes the establishment of a Center for Research on the Ethical, Legal and Social Implications of Psychiatric, Neurologic and Behavioral (PNB) Genetics at Columbia University Medical Center (CUMC). Since April 2010, we have been funded under a P20 Developing Center grant to create the infrastructure and begin development of such a Center. PNB genetics present particular ethical, legal and social challenges because of the highly stigmatized nature of many PNB disorders and traits; the potential impact of genetic predispositions for PNB disorders and traits on perceptions of responsibility for behavior; and the complex interactions between genetic propensities and environmental influences that determine the onset and course of many PNB disorders, rendering the implications of many PNB genetic data inherently ambiguous. Our new Center will promote thoughtful consideration of the range of issues arising in the context of PNB genetics and develop innovative approaches to addressing them. Specifically, we will undertake a focused program of research that explores the impact of PNB genetic information at the individual, familiar and societal levels, considering its effects on stigma and self-image, attributions of responsibility, and responses to ambiguity, along with systematic consideration of the broader normative and policy implications of our findings. To maximize the value of our research, we will create robust mechanisms to translate the empirical and normative output of our research into recommendations for policy and practice, capitalizing on the involvement of other experts and key stakeholder groups. With an eye on the future of ELSI studies, we will develop a multidisciplinary post-doctoral training program focused on nurturing future leaders in ELSI research, creating an environment that facilitates cross-disciplinary learning and research and draws on outstanding mentors and teachers. In sum, we will create a structure that builds on our existing strengths and accomplishments to enhance transdisciplinary collaboration, facilitate the conduct of innovative research, and foster intellectual growth among both faculty and trainees.