P30 - Core Grant for Vision Research

描述（由申请人提供）：埃默里大学和邻近的亚特兰大机构的视觉研究要求继续获得NEI核心基金的支持。这项核心中心拨款更新申请包括三个模块：(1)结构生物学和成像，(2)功能基因组学和蛋白质组学，(3)生物信息学和生物统计学。过去的核心拨款支持了42名教师（包括31名NEI资助的首席研究员的36个单独奖项）、16名博士后、6名博士前研究员的协作视觉研究和服务，并在过去5年里发表了500多篇同行评审的论文。结构生物学和成像模块在现有的免疫组织化学、共聚焦显微镜、荧光图像分析、光学和电子显微镜服务的支持下，在此更新中增加了超声检查。功能基因组学和蛋白质组学模块为啮齿类动物的视觉表型分析增加了新的功能，包括SD-OCT、扫描激光眼科检查、部分相干干涉测量、高精度显微测量、光折射、角镜检查、回弹眼压测量、ERG和OKT

DESCRIPTION (provided by applicant): Continued support is requested forth NEI Core Grant for Vision Research at Emory University and neighboring Atlanta institutions. This Core Center Grant renewal application includes three Modules: (1) Structural Biology and Imaging, (2) Functional Genomics and Proteomics, and (3) Bioinformatics and Biostatistics. The past core grant supported collaborative vision research and service among 42 faculty (including 36 separate awards by 31 NEI funded principal investigators),16 postdoctoral fellows, 6 predoctoral fellows and generated 500+ peer-reviewed publications in the past 5 years. The Structural Biology and Imaging Module adds ultrasonography in this renewal to existing support for immunohistochemistry, confocal microscopy, fluorescence image analysis, and light and electron microscopy services. The Functional Genomics and Proteomics module adds new capabilities for visual phenotyping of rodents, including SD-OCT, scanning laser ophthalmoscopy, partial coherence interferometry, high precision micrometry, photorefraction, gonioscopy, rebound tonometry, ERG, and OKT, to pre-existing services for oligonucleotide synthesis, HPLC analyses, mass spectrometry, PCR, laser capture microdissection, gene and protein sequencing, and microarray analysis. The Bioinformatics and Biostatistics Module provides biostatistics, bioinformatics, data management, electronic notebooks, data backups, and advanced computational analyses. The Core is administered by the Program Director and one-two Module Directors for each of the Modules; a Core Grant Advisory Committee will aid the module directors to insure full and equitable use of the facilities and to advise on creation of new resources based on need or eliminate components that are underutilized. The Core Modules have and will continue to increase research productivity by providing common centralized services to stimulate and facilitate collaborative studies among faculty and to attract other academic disciplines to vision research.