Adminitrative Core

伊萨克森博士将继续担任他在2009年成立的PD IPS财团的领导人，当时ARRA Go Grants(RC2)为PD、ALS和HD财团提供资金。他的经验和领导能力将加强PD IPS财团实现RFA为这笔U24拨款设定的目标的能力。 这个PD iPS联盟现在将被组织成三个项目核心，a)临床和遗传核心(Z.Wszoiek，核心PI)，b)分化和报告核心(L.Studer和D.Krainc，核心PI)，c)细胞功能和病理生理学核心(T.Dawson，核心PI)。这三个核心将得到研究资源核心的支持：行政部门(O.Isacson，CORE PI)和重新规划合同研究组织(CRO)(哈佛干细胞研究所和纽约干细胞基金会)(见协作书)。(组织概述见图1，导言)。这些核心包括在八个不同机构(麦克莱恩/哈佛大学、哥伦比亚大学、梅奥-杰克逊维尔学院、纪念斯隆·凯夫林学院、马萨诸塞州总医院/哈佛大学、约翰霍普金斯大学、宾夕法尼亚大学和西北大学)进行的研究。为了促进成功地完成科学和技术挑战以实现联合体的目标和时间表所必需的协同作用和沟通渠道，行政核心将提供 组织和支持这项U24赠款的管理。 联合会主任奥莱·伊萨克森教授负责确保协调和核心职能得到适当管理。伊萨克森博士在干细胞使用方面的专业知识超过十年，他卓有成效地指导了NIH资助的中心和项目，包括最近为其提供资金的RC2 Go赠款 PD IPS联盟。由于联盟成员之间的互动对于联盟目标的实现至关重要，所以Isacson博士将每两个月在所有核心PI和执行科学委员会成员之间召开一次电话会议(参见图2，简介)。他将推动调查人员之间的持续合作，并将细胞送往科里尔存放。 在日常管理细节方面，桑德拉·波尔曼女士担任麦克莱恩医院/哈佛医学院神经再生研究中心的首席行政人员已有10多年。她的角色是管理资源和资金，并确保根据研究计划和研究成本类别进行适当的会计和支出。她作为一名行政长官的参与体现在所涉及的合作协议上。她之前曾为大型中心赠款和目前的PD IPS财团开展过这样的活动。 波尔曼女士担任关于这项提案的调查员、他们的赠款管理人和受赞助的研究办公室之间的沟通协调员，负责编制和管理预算和研究报告。

Dr. Isacson will continue the role of leader of the PD IPS consortium that he began in 2009, when the ARRA GO grants (RC2s) funded the PD, ALS and HD consortia. His experience and leadership will strengthen the ability of the PD IPS consortium to achieve the goals set out in the RFA for this U24 grant. This PD iPS Consortium will now be organized into three Project Cores, a) Clinical and Genetic Core (Z. Wszoiek, core PI), b) Differentiation and Reporter Core (L. Studer and D. Krainc, core Pis), c) Cell Function and Pathophysiology Core (T. Dawson, core PI). These three cores will be supported by the research resource cores: Administration (O. Isacson, core PI) and the Reprogramming contract research organizations (CROs) (Harvard Stem Cell Institute and New York Stem Cell Foundation) (see letters of collaboration). (For overview of organization, see Fig. 1, Introduction). The cores include research studies at eight separate institutions (McLean/Harvard, Columbia, Mayo-Jacksonville, Memorial Sloan Keftering, Massachusetts General Hospital/Harvard, Johns Hopkins University, University of Pennsylvania and Northwestern University. In order to foster the synergies and lines of communication necessary for the successful achievement of the scientific and technical challenges to achieving the consortium goals and timelines, the Administrative Core will provide the organization and support for the administration of this U24 grant. The Consortium Director, Prof Ole Isacson, is responsible for ensuring that coordination and core functions are appropriately managed. Dr. Isacson's expertise in stem cell use exceeds a decade, and he has productively directed NIH-funded Centers and Programs, including the recent RC2 GO grant that currently funds this PD IPS Consortium. Because the interactions between the members of this Consortium are essential to the accomplishment of the Consortium goals, Dr. Isacson will hold a conference call every 2 months between all of the Core Pis and the members of the Executive Science Committee (see Fig. 2, Introduction). He will promote the continuous cooperation between investigators, and the sending of cells for deposit to Coriell. On the administrative day-to-day detail, Ms. Sandra Pohlman has been the chief administrator of the Center for Neuroregeneration Research at McLean Hospital/Harvard Medical School for over 10 years. Her role is to manage resources and funds, and ensure proper accounting and spending according to the research plan and research cost categories. Her involvement as an Administrator is exemplified by the cooperative agreements involved. She has carried out such activities previously for large Center grants and the current PD IPS consortium. Ms. Pohlman serves as the coordinator for communication between the investigators on this proposal, their grants administrators and sponsored research offices for preparation and administration of budgets and research reports.