FASEB SRC on Ion Channel Regulation

描述(申请人提供)：离子通道和转运体应该占人类基因的1%，深入研究它们由遗传突变造成的破坏不仅是为了更多地了解它们的生理学，也是为了开发治疗策略来治疗遗传性‘通道病’，还可以治疗或避免更广泛的疾病，其中通道是引起和/或潜在的治疗靶点，例如药物引起的心律失常和癫痫。对突变离子通道的研究使人们对疾病的分子基础有了前所未有的了解，因为可以使用单通道膜片钳技术来研究单个突变蛋白，以确定通道疾病的精确分子病因学，并通过在临床上针对离子通道的药物的新方法的明智应用，为通道障碍的治疗创造了一个平台。在我们对通道病的理解中，正在向前迈出的重要一步是发现了一些调节离子通道功能的调节蛋白，当这些蛋白在遗传性疾病中突变时，也会扰乱天然离子电流，并为一系列病理奠定基础。这次会议以离子通道调节为主题，围绕着遗传性通道病这一相对较新的方面。这一主题为合作、跨学科互动以及跨学科和多学科研究培训提供了绝佳的机会。这是申请第六届FASE B夏季离子通道调节研究会议的部分资助。会议将于2013年6月23日至28日在巴哈马拿骚的喜来登度假村举行。这笔赠款的资金将专门用于支付20名受训人员(研究生、博士后研究员)的注册费、住宿费、餐费和参加会议的旅费。这次会议旨在强调与离子通道调节相关的最新发现，并介绍新的概念和技术方法。会议的目标是促进渠道监管研究的新合作和新方向，并通过为初级调查人员提供向该领域领先研究人员学习和发展关系的机会来促进他们的发展。这次会议以前促进了科学小组之间新的跨学科合作，并由于会议期间和会议后发生的协同互动而刺激了更快的进展。2013年会议的联合主席将是杰弗里·W·阿博特博士(加州大学欧文分校)和杰弗里·S·皮特博士(杜克大学)，他们都是离子通道生物学领域公认的领导者，重点是通道调节。该方案包括9个科学会议、1个主旨演讲和一个题为“妇女在科学中的挑战和机遇”的小组会议。大多数会议都是围绕一般主题而不是离子通道亚型组织的，以促进传统会议中通常保持独立的领域之间的串扰。计划中的几个讲座集中在罕见疾病(经络病)的分子和细胞基础上。在37位作了全面发言的发言者中，有11位是女性(30%的发言者；9位会议主席中有5位也是女性)，2位是科学界代表性不足的团体的成员。将从提交的摘要中挑选八个简短的讲座，并邀请早期调查人员，重点是邀请妇女、科学界代表性不足的少数群体和受训人员；我们还将与加勒比地区的机构合作，鼓励他们参与，从而鼓励新的合作。会议场地为残障人士提供了适当的设施。

DESCRIPTION (provided by applicant): Ion channels and transporters are ought to account for 1% of human genes, and their disruption by inherited mutations is intensively studied as a means not only to learn more about their physiology, but also to develop therapeutic strategies to treat inherited 'channelopathies' and also to treat or avoid more widespread disorders in which channels are causative and/or potential therapeutic targets, e.g., drug- induced cardiac arrhythmias, and epilepsy. Study of mutant ion channels has permitted an unprecedented understanding of the molecular basis of disease, as single mutant proteins can be studied using single channel patch-clamp techniques to determine the precise molecular etiology of channelopathies and created a platform for the treatment of channel disorders through the judicious application in new ways of clinically available drugs targeting ion channels. A major and ongoing step forward in our understanding of channelopathies has been the discovery of a number of regulatory proteins, which modulate ion channel function and which, when mutated in inherited disorders, also disrupt native ionic currents and underlies a range of pathologies. This conference, with its theme of ion channel regulation, encompasses this relatively new aspect of inherited channelopathies. This theme provides outstanding opportunities for collaboration, cross-disciplinary interactions, and interdisciplinary and multidisciplinary research training. Ths is an application for partial support of the 6th biennial FASEB Summer Research Conference on Ion Channel Regulation. The conference will be held June 23-28, 2013 at the Sheraton Resort, Nassau, Bahamas. Funds from this grant will be used exclusively to support registration fees, lodging, meals and travel to the conference for 20 trainees (graduate students, postdoctoral fellows). This meeting is designed to highlight the latest discoveries related to ion channel regulation and introduce novel conceptual and technological approaches. The goal of the meeting is to promote new collaborations and directions for research on channel regulation and to foster the development of junior investigators by offering them the chance to learn from, and develop relationships with, leading researchers in the field. This conference has previously fostered new cross-discipline collaborations among scientific groups and has stimulated more rapid advances because of synergistic interactions that occurred during and after the meeting. The Co-chairs of the 2013 conference will be Dr. Geoffrey W. Abbott (University of California, Irvine) and Dr. Geoffrey S. Pitt (Duke University), both recognized leaders in ion channel biology with an emphasis on channel regulation. The Program consists of nine scientific sessions, 1 keynote address, and a panel session titled "Challenges and Opportunities for Women in Science". Most sessions were organized around general themes rather than ion channel subtype, to foster crosstalk between fields typically kept separate in traditional conferences. Several of the planned talks focus upon the molecular and cellular basis of rare diseases (channelopathies). Of the thirty-seven speakers giving full talks, 11 are women, (30% of speakers; 5 of 9 session chairs are also women), and 2 are members of groups underrepresented in science. Eight short talks will be selected from submitted abstracts and invited early stage investigators, with an emphasis on inviting women, minorities underrepresented in science and trainees; we will also work with institutions within the Caribbean to encourage their participation, thereby encouraging novel collaborations. The conference venue has appropriate facilities for disabled attendees.