Ion Mobility Spectrometry Methods Used for On-line Measurements of Biopharmaceuti

描述：第一阶段SBIR项目的最终目标是建立使用离子迁移率谱法（IMS）或液相色谱-IMS （LC-IMS）作为快速、选择性和敏感的方法来在线快速监测生物制造过程的可行性，以提高对过程的理解并提供实时反馈。Excellims将开发LC-IMS方法，用于监测最重要的化学物质，为过程监控人员提供信息。生物制造商受到当前实时监控工具的限制，必须在产品完成后确定质量。因此，该方法的成功开发将满足对提高整个过程效率的工具的需求

DESCRIPTION: The ultimate goal of the Phase I SBIR project is to establish the feasibility of using ion mobility spectrometry (IMS) or liquid chromatography-IMS (LC-IMS) as a fast, selective and sensitive method for rapid monitoring of bio manufacturing processes for on-line use to improve the understanding of the process and provide real-time feedback. Excellims will develop the LC-IMS method for monitoring the most important chemical species that inform the process monitors. Bio manufacturers are limited by current real-time monitoring tools and must determine quality after the product is completed. Therefore, successful development of the method will fulfill the need for tools that increase the efficiency of the entire process that will translate into operational and cost savings for mass producing biologics.