Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders

描述（由申请人提供）：睡眠医学是一个相对较新的学科。因此，很少有机构有足够的教师来设立单一的机构培训补助金。缺乏研究培训是睡眠医学领域利用当前科学机会的主要障碍。有大量新科学机会的一个领域是遗传/基因组方法领域。这些都是开发个性化睡眠药物所必需的。许多睡眠障碍是可遗传的，尽管赋予风险的基因变异在很大程度上是未知的。此外，最近已经在许多物种中发现了类似睡眠的状态，如蠕虫，果蝇和斑马鱼以及小鼠。这些模型系统可用于确定人类研究中鉴定的基因变异的功能意义。为了利用这些机会，提出了一项新的国家努力。其基础是一项多机构培训赠款，涉及三个机构-约翰霍普金斯大学、斯坦福大学和密歇根大学。该计划将由宾夕法尼亚大学与这三个机构的研究员指导。宾夕法尼亚大学在睡眠研究培训方面拥有最丰富的经验，并拥有重要的行政和培训基础设施来支持这一计划。该计划将侧重于培养下一代医学科学家。受训人员将在该方案的支持下接受三年的培训。将有一个核心课程，将采取的所有学员。这将使用已经投入使用的基于视频的新IT技术。核心课程将包括以下内容： 由所有参与机构的教员举办关于睡眠及其紊乱的遗传学/基因组学的研讨会;职业发展;赠款讲习班;期刊俱乐部;受训人员进行中的研究讲座。每个受训者将在他们的家乡机构有共同的导师-一个睡眠研究专家和一个遗传学/基因组学专家。他们还将有一个由睡眠研究和遗传学专家组成的指导委员会。对于指导委员会，来自该计划的各个机构以及目前资助睡眠研究培训计划的机构（哈佛，宾夕法尼亚大学，匹兹堡）的导师将在适当的情况下参与。在这些其他机构从事遗传/基因组研究的受训人员也将被视为这一国家努力的一部分。每年将有一次全体学员和教员的务虚会。这将使新学员获得研究机会，并使更高级的学员能够介绍他们的研究。还将由受训人员挑选主旨发言人。这次务虚会将促进 在所有不同的地点受训。这项全国性工作的目标是培养一批新的研究人员，研究睡眠及其障碍的遗传/基因组方法。

DESCRIPTION (provided by applicant): Sleep medicine is a relatively new discipline. Hence, few institutions have the critical mass of faculty to mount a single institutional training grant. he lack of research training is a major barrier for the field of sleep medicine to take advantage of current scientific opportunities. One area where there are substantial opportunities for new science is in the field of genetic/genomic approaches. These are needed to develop personalized sleep medicine. Many sleep disorders are heritable, although the gene variants that confer risk are largely unknown. Moreover, recently sleep-like states have been identified in many species such as worms, fruit flies and zebra fish as well as mice. These model systems can be used to determine the functional significance of gene variants identified in human studies. To capitalize on these opportunities, a novel national effort is proposed. The basis of this is a multi-institutional training grant involving three institutions-Johns Hopkins, Stanford University and University of Michigan. The program will be directed by the University of Pennsylvania with fellows at each of these three institutions. The University of Pennsylvania has the most experience in research training in sleep and has significant administrative and training infrastructure to support this program. The program will focus on training the next generation of physician-scientists. Trainees will be given three years of training supported by this program. There will be a core curriculum that will be taken by all trainees. This will use new video-based IT technology that is already operational. The core curriculum will involve the following: lectures on genetics/genomics of sleep and its disorders by faculty at all participating institutions; caree development; grants workshop; journal club; research-in-progress talks by trainees. Each trainee will have co- mentors at their home institution-one expert in sleep research and one in genetics/genomics. They will also have a mentorship committee with experts in sleep research and genetics. For the mentorship committee, mentors from the various institutions in this program, as well as from institutions that currently have funded training programs in sleep research (Harvard, Penn, Pittsburgh) will be involved, if appropriate. Trainees who pursue genetic/genomic research at these other institutions will also be considered part of this national effort. There will be an annual retreat of all trainees and faculty. This will orient new trainees o research opportunities and allow more advanced trainees to present their research. There will also be keynote speakers selected by trainees. This retreat will facilitate interaction between the trainees at all the different sites. The goal of this national effort is to develop a cadre of new investigators in genetic/genomic approaches to sleep and its disorders.