International EMT meeting

描述（由申请人提供）：本提案的具体目的是为参加第六届上皮-间质转化国际会议的美国年轻学术演讲者和学生获得部分费用（旅费和住宿费）。会议将于2013年11月13日至15日在西班牙阿利坎特举行，由上皮-间充质转化国际协会（TEMTIA）主办。会议的目标是1。将癌症、病理学和发展等不同学科的研究人员聚集在一起，讨论他们对EMT的观察，并探讨是否对该过程的重要组成部分达成共识。2. 提供一个论坛，学生和初级研究人员可以与高级研究人员互动，并展示他们在该领域的工作和想法。3. 为国际上与EMT相关的研究人员扩大一个可行的跨学科合作论坛。这将继续为跨学科的专业知识、试剂和技术交流提供一个全球网络。上皮-间充质转化（Epithelial-mesenchymal transition， EMT）是胚胎细胞从细胞片形成三维结构的基本细胞过程。在EMT过程中，上皮细胞失去与邻近细胞的粘附，降解局部基底膜并侵入下层间质细胞外基质。在细胞水平上，这一过程需要特定的信号转导元件、新的基因转录、细胞骨架的重组、细胞外基质分子和生长因子的分泌。在胚胎中，这一过程在原肠胚形成、神经嵴细胞形成、心脏形成和其他器官发生过程中重复。在成人中，EMT作为伤口愈合的一个组成部分，在癌症转移和组织纤维化的病理中发生。自从第一次TEMTIA会议以来，该领域的发展非常迅速，现在每年都有1200多篇关于该主题的论文发表。这次会议是一个重要的会议，将继续影响该领域的转化进展。

DESCRIPTION (provided by applicant): The specific aim of this proposal is to obtain partial funding for expenses (travel and lodging) for younger academic speakers and students from the USA to attend the 6th International Meeting on Epithelial-Mesenchymal Transition. The meeting will be held Nov 13-15, 2013 in Alicante, Spain under the auspices of the Epithelial-Mesenchymal Transition International Association (TEMTIA). The objectives of the meeting are to 1. Bring together investigators in the separate disciplines of cancer, pathology and development to discuss their observations on EMT and explore whether there is a consensus on important components of the process. 2. Provide a forum where students and junior investigators can interact with senior investigators and display their own work and ideas in the field. 3. Expand a viable co-operative cross- disciplinary forum of EMT- related researchers internationally. This will continue to provide a worldwide network for exchange of expertise, reagents and techniques across disciplines. Epithelial-mesenchymal transition (EMT) is a fundamental cellular process undertaken by cells in the embryo to form 3-dimensional structures from sheets of cells. During EMT, epithelial cells lose adherence to adjacent cells, degrade the local basement membrane and invade the underlying interstitial extracellular matrix. At the cellular level, this process requires specific signal transduction elements, new gene transcription, reorganization of the cytoskeleton, secretion of extracellular matrix molecules and growth factors. In the embryo, this process is reiterated at gastrulation, neural crest cell formation, heart formation and in several other areas of organogenesis. In the adult, EMT occurs as a component of wound healing and in the pathologies of cancer metastasis and tissue fibrosis. Since the first of these TEMTIA meetings, the growth of the field has been dramatic and there are now more than 1200 primary papers published each year on the topic. The meeting is an important one that continues to shape the translational progress in the field.