TRANSLATIONAL AIDS AND VIRAL PATHOGENESIS TRAINING (51)

描述(由申请者提供)：我们的目标是培训加州大学洛杉矶分校(UCLA)传染病医学博士或医学博士/博士研究生，从事艾滋病和慢性病毒发病机制的翻译研究。随着全球病毒性疾病(如HIV-1和丙型肝炎)负担的增加和基础科学研究的增加，开发成功的治疗方法和疫苗的一个关键瓶颈是转化性研究。因此，迫切需要合格的内科科学家研究人员，他们可以从工作台到床边工作。 鉴于加州大学洛杉矶分校在翻译/基础HIV-1研究和基础病毒学研究方面的整体实力，我们提出了一个主要专注于HIV-1的培训计划，并为研究员提供机会进行其他病毒的翻译发病机制研究。我们已经组建了一个高度精选的教职员工团队，作为潜在的导师，他们跨越了加州大学洛杉矶分校的几个系。将鼓励学员充分利用参与的基础科学和临床教师之间的众多合作，以创造独特的翻译研究机会。研究导师有积极的IRB方案来招募研究艾滋病毒和丙型肝炎病毒发病机制的受试者，积极参与新型抗病毒疗法的人体试验，并几乎研究艾滋病毒发病机制的所有方面。许多教师导师也在研究丙型肝炎病毒复制和持久性的基本方面。 我们的计划将支持MD实习生(获得博士学位)或MD/博士后实习生(寻求正式的博士后培训)，作为其传染病子专业培训的一部分。我们将每年寻找一名合格的实习生，在任何时候最多有3名实习生参加该计划。我们的计划旨在为学员提供大量受保护的研究时间，以便他们可以培养独立的研究兴趣，并获得独立的资金。这一培训计划的最终目标是让所有受训人员最终成为独立调查人员。 相关性：这笔培训赠款将支持新的内科科学家的发展，作为我们培训计划的结果，研究艾滋病和慢性病毒发病机制的合格个人的数量将会增加。科研队伍的增加将加快发现抗击艾滋病和其他慢性病毒感染(如丙型肝炎)的新方法的速度。

DESCRIPTION (provided by applicant): Our goal is to train infectious disease MD or MD/PhD postdoctoral fellows at University of California Los Angeles (UCLA) in translational research in AIDS and chronic viral pathogenesis. With an increasing global disease burden of viral diseases (such as HIV-1 and viral hepatitis C) and increasing basic scientific research, a key bottleneck for developing successful therapies and vaccines is translational research. There is therefore a pressing need for qualified physician-scientist researchers who can work from bench to bedside. Given the overall strength of UCLA in translational/basic HIV-1 research and basic virology research, we propose a training program that is predominately focused on HIV-1, with opportunities for fellows to pursue translational pathogenesis studies on other viruses as well. We have assembled a highly selected group of faculty members to serve as potential mentors, spanning several UCLA departments. Trainees will be encouraged to take full advantage of the numerous collaborations between participating basic science and clinical faculty in order to create unique translational research opportunities. Research mentors have active IRB protocols to recruit subjects for the study of HIV and HCV pathogenesis, are actively involved with human trials for novel antiviral therapeutics, and are studying virtually all aspects of HIV pathogenesis. Many faculty mentors are also studying fundamental aspects of HCV replication and persistence. Our program will support MD trainees (leading to a PhD) or MD/PhD trainees (seeking formal postdoctoral training) as part of their Infectious Diseases subspecialty training. We will be seeking one well-qualified trainee each year with maximum 3 trainees in the program at any time. Our program is structured to provide trainees with significant protected research time so that they may develop independent research interests and secure independent funding. The ultimate goal of this training program is for all trainees to ultimately succeed as independent investigators. RELEVANCE: This training grant will support the development of new physician-scientists, and as a result of our training program there will be an increase in the number of well-qualified individuals studying AIDS and chronic viral pathogenesis. This addition to the scientific workforce will increase the tempo of discovery of new approaches to combat AIDS and other chronic viral infections such as Hepatitis C.