HIV and Aging: From the Mitochondria to the Metropolis

描述(申请人提供)：HIV与衰老：从线粒体到大都会。 这一R13应用的主要目的是：a)举办3次扩大地理范围(南部地区、国家、国际)的年度会议，旨在增加艾滋病毒和老龄化科学的研究并推动其向前发展；以及b)增加关注这一领域差距的不同早期调查人员的渠道。艾滋病研究办公室(OAR)艾滋病毒与老龄化工作组(WG)的调查结果和建议构成了我们会议的基础和框架。我们的目的是吸引和汇聚专家、临床医生、 来自艾滋病毒和老龄化领域的早期调查人员和社区领导人。我们期望这些会议将产生以下成果：a)增加该领域的知识，并提供一个可行的机制，将基础和临床科学成果转化为艾滋病毒/艾滋病患者(PLWH)社区(即从“线粒体到大都市”)；b)成立特别兴趣小组，将重点放在临床和研究方面的差距；c)开发研究人员和与工作组概述的议程相关的研究建议，并通过会议付诸实施；d)在广泛的专业人员和会议场所传播会议内容。会议将由执行委员会和科学委员会策划，并有大量社区代表参加。执行局将由来自Emory‘s CFAR、健康与老龄化中心和阿尔茨海默病研究中心的Co-Pi领导，CFARs和南方老龄中心以及艾滋病毒和老龄问题国际工作组将密切合作。第一次和第三次会议将在佐治亚州亚特兰大(埃默里大学CFAR)举行；第二次会议将在北卡罗来纳州达勒姆(杜克大学CFAR)举行。其目标是：1.主办3次扩大地域范围的年度会议，以解决和翻译审查组工作组概述的知识和研究方面的差距。所有会议将包含以下概念的线索：虚弱(包括多发病、功能衰退和疾病脆弱性)、慢性炎症、个性化护理和护理影响(包括对非正式照顾者)。内容范围从基础/生理科学、临床护理和翻译到更广泛的社区将包括在内。我们将会有一个“线粒体到大都会”的主题。具体焦点包括：第1年(2014年；区域)：多发病；第2年(2015；国家)：生物标志物；第3年(2016；国际)：社会基础设施和特殊人群(妇女、男男性接触者、LGBT、吸毒者、少数群体)的护理问题。2.创建和建立不同多学科科学家的渠道，他们将进行转化性研究，重点是与艾滋病毒和老龄化有关的知识和研究方面的差距。我们将：邀请NIH/HRSA/CDC主要组织的项目官员讨论战略优先事项和资助机会；建立艾滋病毒与老龄化列表服务器，提供信息和合作论坛；形成研究特别兴趣小组，并包括为早期研究人员设立有组织的辅导日部分。

DESCRIPTION (provided by applicant): HIV and Aging: From the Mitochondria to the Metropolis. The primary aims of this R13 application are to: a) conduct 3 annual conferences of expanding geographical scope (Southern region, national, international) aimed at increasing research and moving the science in HIV and Aging forward; and b) increase the pipeline of diverse early stage investigators focused on the gaps in this area. The findings and recommendations from the Office of AIDS Research (OAR) Working Group on HIV and Aging (WG) form the foundation and framework for our conferences. Our intent is to attract and bring together experts, clinicians, early stage investigators, and community leaders from the fields of both HIV and Aging. We expect these conferences to lead to the following outcomes: a) increase knowledge in the field and provide a viable mechanism for translating basic and clinical science findings to the community of persons living with HIV/AIDS (PLWH) (i.e., from the "mitochondria to the metropolis"); b) formation of special interest groups that will focus on clinical and research gaps c) development of researchers and research proposals related to the agenda outlined by the WG and operationalized via the conferences; d) dissemination of conference content across a broad range of professionals and venues. The conferences will be planned by Executive and Scientific Boards with substantial representation from the community. The Executive Board will be led by Co- PI's from Emory's CFAR, Center for Health and Aging, and Alzheimer's Disease Research Center with strong collaboration by CFARs and Centers for Aging in the South and the HIV and Aging Inter-CFAR Working Group. The first and third conference will be in Atlanta, GA (Emory University CFAR); the second will be in Durham, NC (Duke University CFAR). The aims are: 1. Host 3 annual conferences of expanding geographical scope and reach that address and translate gaps in knowledge and research outlined by the OAR WG. All conferences will contain threads of the following concepts: Frailty (encompassing multimorbidity, functional decline, and vulnerability to illness), Chronic Inflammation, Personalized Care, and Care Implications (including for informal caregivers). Content ranging from basic/physiologic science, clinical care, and translation to the broader community will be included. We will have a "Mitochondria to Metropolis" theme. Specific foci include: Year 1 (2014; Regional): Multimorbidities; Year 2 (2015; National): Biomarkers; Year 3 (2016; International): Societal Infrastructure and Caregiving Issues with Special Populations (Women, MSM, LGBT, Substance users, Minorities). 2. Create and build a pipeline of diverse multidisciplinary scientists who will conduct translational research focused on the gaps in knowledge and research related to HIV and Aging. We will: Invite program officers from key NIH/HRSA/CDC organizations to discuss strategic priorities and funding opportunities; establish an HIV and Aging listserv which will provide a forum of information and collaboration; form research special interest groups, and include a structured mentoring day component for early stage researchers.