Collaborative Observational Study of Myopia in COMET Children 2 (COSMICC2) Chair

描述(由申请人提供)：关于近视进展的减缓、其最终稳定以及相关危险因素的数据有限。青少年近视通常被认为在15-16岁时停止进展，然而来自成年人的数据显示，这种进展有时可以持续到20岁的S。对参加彗星儿童近视合作观察研究(COSMICC)的受试者的屈光数据分析表明，目前平均年龄为17岁的近视仅有42%的人停止进展。这组不同种族的近视受试者有7-8年的屈光不正和眼睛成分的标准化、可靠的测量，突出的保留率为93%。因此，这个队列提供了一个独特的机会来描述近视的进展和稳定，并了解从本研究和文献中确定的内在因素(例如，年龄、种族)和环境因素(例如，配戴的镜片类型、附近工作和户外活动)是如何影响近视的。由于在我们的一些受试者中发现了较高的近视率(患近视6.0D者占22%)，我们还计划调查眼压(IOP)、中央角膜厚度(CCT)和黄斑厚度与近视进展和眼轴延长的关系。这些结果将有助于识别近视相关病理风险增加的个体，并有助于指导干预措施的选择和时机，包括视力矫正手术。通过对这一队列再研究5年，本申请旨在实现以下目标。目的1：使用Gompertz和其他功能来描述COSMICC队列中58%的进展性近视的近视过程，并基于先前确定的内在危险因素(年龄、种族和父母近视)建立预测模型。目的2：检验与环境风险因素(如配戴的镜片类型、附近工作和户外活动)有关的假设，以促进近视进展和稳定在这一特征良好的近视队列中。目的3：在COSMICC受试者中，检验眼压、中央角膜厚度和黄斑厚度与眼轴延长和近视进展之间关系的假说。此申请表是针对COSMICC2研究会主席的。4个临床中心和协调中心分别提交了申请。

DESCRIPTION (provided by applicant): Limited data are available on the slowing of myopia progression, its eventual stabilization, and related risk factors. Juvenile-onset myopia typically is thought to stop progressing at 15 -16 years of age, yet data from adults show that progression can sometimes continue at least through the 20's. Analysis of refraction data from subjects enrolled in the Collaborative Observational Study of Myopia in COMET Children (COSMICC) shows that currently, at an average age of 17 years, myopia has stopped progressing in only 42% of the cohort. This group of ethnically diverse myopic subjects has 7-8 years of standardized, reliable measurements of refractive error and ocular components, with outstanding retention of 93%. Thus, this cohort provides a unique opportunity to characterize progression and stabilization of myopia and to learn how they are influenced by intrinsic (e.g., age, ethnicity) and environmental factors (e.g., type of lens worn, near work and outdoor activities) identified from this study and from the literature. With the higher amounts of myopia found in some of our subjects (22% with > 6.0 D), we also plan to investigate the association of increased progression and axial elongation with intraocular pressure (IOP), central corneal thickness (CCT), and macular thickness. These results will help to identify individuals with increased risk of myopia-related pathology as well as help guide the selection and timing of interventions, including vision correction surgery. By studying this cohort for an additional 5 years, this application seeks to accomplish the following aims. Aim 1: To use the Gompertz and other functions to characterize the course of myopia in the 58% of the COSMICC cohort with progressing myopia and to develop predictive models based on previously identified, intrinsic risk factors (age, ethnicity, and parental myopia). Aim 2: To test hypotheses related to environmental risk factors (e.g., type of lens worn, near work and outdoor activities) for myopia progression and stabilization in this well-characterized cohort of myopes. Aim 3: To test hypotheses related to the association of IOP, CCT, and macular thickness with changes in axial elongation and myopia progression in COSMICC subjects. This application is for the COSMICC2 Study Chair. Separate applications have been submitted by the 4 clinical centers and the Coodinating Center.