Assessment Core

评估核心有三个主要目标。首先是确定大约150名新参与者，参与我们计划项目下一阶段所有子项目正在进行的研究。确定过程将包括在纽约州立研究所或发育障碍基础研究（IBR）协调人类参与者审查，以及为新参与者获得知情同意。我们还将为我们之前研究中的约150名参与者获得新的知情同意，这些参与者将继续参加我们的项目，另外还有20 - 30名年轻人。 将在子项目3中进行研究的唐氏综合征成年患者。核心的第二个主要目标是与子项目1、2、3和4内的研究人员密切合作，协调并对我们的300名研究参与者进行全面评估。我们的第三个目标，与子项目1，2，3，4和遗传学核心密切合作，将从项目参与者中收集血液样本，用于分析甲基化的生物标志物，基因型和表观遗传学研究。第四个目标是将评估数据输入我们的核心数据库，以便于按计划子项目进行分析，并维护一个单独的参与者跟踪数据库。这些活动将确保所有计划参与者都使用标准化的 程序和共同的措施，提供了丰富的描述表型，促进个别子项目内的分析，并支持子项目之间的互动。

The Assessment Core has three major goals. The first is to ascertain approximately 150 new participants for the studies being conducted by all of the Subprojects within this next phase of our Program Project. The ascertainment process will include coordinating human participant reviews at the New York State Institute or Basic Research in Developmental Disabilities (IBR), as well as obtaining informed consent for new participants. We will also obtain new informed consents for the approximately 150 participants from our previous studies that will be continuing enrollment in our program, and an additional group of 20 - 30 younger adults with Down syndrome who will be studied in Subproject 3. The second major goal of the Core is to coordinate and conduct comprehensive assessments of our 300 study participants in close collaboration with investigators within Subprojects 1, 2, 3 and 4. Our third goal, in close collaboration with Subproject 1, 2, 3, 4 and the Genetics Core, will be to collect blood samples from program participants for analyses of biomarkers, genotype and epigenetic studies of methylation. The fourth goal will be to enter data from assessments into our Core database to facilitate analyses by Program Subprojects, and to maintain a separate participant tracking database. These activities will ensure that all Program participants are characterized using standardized procedures and common measures, providing rich descriptions of phenotype, facilitating analyses within individual Subprojects, and supporting interactions among Subprojects.