TAS::75 0872::TAS HEART&VASCULARCONTRACTS/IAA(8470187)

1.研究活动 这些研究的基本主题是心血管疾病预防和管理的一体化，强调框架各组成部分之间的协同作用、互补性和相互依存性。 a.中美洲与心血管疾病相关的饮食风险因素的最新进展-对居住在中美洲9个国家的540名成人和270名7-12岁学龄儿童进行的横断面研究。每个国家30个孩子和他们的父母。将采集生物样本。 B.为改善危地马拉城市贫困地区小学生的心血管健康而进行的多层次干预试验-目标人群是7-12岁的儿童及其父母。为了表征CVD风险因素，他们将招募90名健康儿童，其中45名体重正常，45名超重。就目前的知识和态度而言，24-32名儿童、家长、教师和保健提供者以及8名教育或市政当局。为了验证工具箱和战略，将征聘10名教师和10名保健提供者。为了进行可行性和有效性评估，他们将招募300对儿童/母亲。 C.预防和控制哥斯达黎加和墨西哥南部城市地区高风险人群心血管疾病的初级卫生保健/社区模式调整并验证糖尿病和高血压患者心血管疾病预防的干预模式。目标人群包括成年人（>30岁）年龄，共300人，每个国家150人。 2.培训 培训将被纳入一个理论框架，通过基础设施和系统开发等其他组成部分加强能力建设。培训方面将侧重于通过短期培训课程培训研究生和初级研究人员，咨询国际公认的心血管疾病研究人员，硕士和博士级培训。 将为初级工作人员建立一个基础设施，以进行他们的研究。活动包括工作小组会议、跨部门/学科会议、师友关系、支援试验计划，以及接驳环球网以促进遥距学习。

1. Research Activities The underlying theme of the studies is the integration of the CVD prevention and managements, with an emphasis on the synergy, complementarity and interdependence between each component of the framework. a. State-of-the art of dietary risk factors associated with CVD in Mesoamerica-- Cross-sectional study in 540 adults and 270 school children 7-12 years old and living in 9 countries in Mesoamerica. 30 children per country and their mothers and fathers. Biological samples will be collected. b. Testing a multilevel-based intervention for the improvement of cardiovascular health in elementary school children living in poor urban areas in Guatemala-- Target population is children 7-12 years of age and both their parents. For characterization of CVD risk factors they will recruit 90 health children, 45 with normal weight and 45 overweight. For current knowledge and attitudes 24-32 children, parents, teachers and health providers and 8 education or municipality authorities. For validation of a tool box and strategies, 10 teachers and 10 health care providers will be recruited. For feasibility and effectiveness assessment they will recruit 300 child/mother pairs. c. Primary health care/community-based model for the prevention and control of CVD in high risk individuals living in urban areas of Costa Rica and Southern Mexico¿Adapt and validate an intervention a model for CVD prevention in patients with diabetes and high blood pressure. Target population includes adults (>30 y) age, a total of 300, 150 in each country. 2. Training Training will be embedded into a theoretical framework that enhances capacity building with additional components like infrastructure and system development. The training aspect will focus on training of graduate students and junior investigators through short training courses, consultation from internationally recognized researches on CVD, master and doctoral ¿level training. An infrastructure will be built for junior staff to carry on their research. Activities include working group meetings, cross sectional/discipline meetings, mentorship, support d pilot projects and on-line access to world-wise web to facilitate distance learning.