Bariatric Surgery Clinical Research Consortium

减肥手术纵向评估（LABS）联盟成立于2003年， 设想解决肥胖症和病态肥胖症的减肥手术和代谢中的重要问题。 LABS探索患者特征、临床状况、血清学和遗传标志物之间的关系， 以及临床、社会心理和卫生经济成果。 实验室的主要成就是建立了一个研究联合体及其基础设施; 定义探索领域，具体的研究问题和有效的研究设计，以有效地 解决这些问题;确定适当的衡量标准;设计和实施基于网络的数据收集 系统和一个广泛的数据库;完成一个超过5000名参与者的队列研究的短期 减肥手术的安全性;招募2000多人进入一个人群，旨在成为 长期随访，以解决减肥手术的安全性和有效性;并实施2项子研究 专注于糖尿病解决机制和更深入的精神病学和生活质量数据， 比在整个队列中分别。 在这个拟议的实验室延续期间，我们将建立在9个国家严格的研究基础设施上。 6个临床中心的临床研究中心实验室研究者将讨论具有科学意义的研究 制定并制定了方案，包括30天的结局（安全性，LABS-1）研究， 大约5，000名参与者和2，400名参与者的较小队列进行详细研究， 减肥手术的纵向效应LABS-3糖尿病是减肥机制的子研究 以及对胃旁路手术患者2型糖尿病的影响。 本提案是OHSU对NIDDK征求意见发布的有限竞争RFA的回应 目前参与LABS联盟的研究者的合作协议申请， 研究减肥手术及其在了解肥胖及其并发症方面的作用， 年LABS的扩展将评价手术的新兴效应和随时间变化的效应。 相关性（参见说明）： 在美国，超过5%的成年人符合减肥手术的体重标准， 符合条件的患者每年接受该治疗。有必要进行研究以确定获益和风险， 告知关于在符合条件的患者中应进行减肥手术的程度的问题。

Longitudinal Assessment of Bariatric Surgery (LABS) consortium was established in 2003 and was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese. LABS explores relationships of patient characteristics, clinical conditions, serologic and genetic markers, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS have been to establish a research consortium and its infrastructure; define the domains of exploration, specific research questions and an effective study design to efficiently address those questions; identify appropriate metrics; design and implement a web-based data collection system and an extensive database; complete a cohort of over 5000 participants to study the short-term safety of bariatric surgery; enroll over 2000 people into a person cohort intended to be the focus of longer-term follow-up to address safety and efficacy of bariatric surgery; and implement 2 sub studies focusing on the mechanisms of diabetes resolution and more in-depth psychiatric and quality of life data, respectively, than in the full cohort. During this proposed continuation of LABS we will build on the rigorous research infrastructure across 9 clinical sites at the 6 Clinical Centers LABS investigators will address scientifically important Research protocols were developed and instituted to include a 30 day outcomes (safety, LABS-1) study of approximately 5,000 participants and a smaller cohort of 2,400 participants to conduct a detailed study of the longitudinal effects of bariatric surgery. LABS-3 diabetes is a sub-study of mechanisms of weight loss and impact on type 2 diabetes in gastric bypass patients. This proposal is the OHSU response to the limited competition RFA issued by the NIDDK soliciting cooperative agreement applications from investigators currently participating in the LABS consortium to study bariatric surgery and its role in the understanding of obesity and its complications for an additional five years. An extension to LABS will evaluate emerging effects of surgery and effects that change overtime. RELEVANCE (See instructions): More than 5% of adults in the US meet the weight criteria for bariatric surgery but less that 2% of the eligible patients undergo this therapy per year. Research to define the benefits and risks is necessary to inform the question regarding the extent to which bariatric surgery should be done in eligible patients.