Expansion and Enhancement of the Arkansas FERN Chemistry Laboratory

项目摘要 大型事件，如2010年深水地平线石油钻井平台爆炸和婴儿配方奶粉被故意 在中国的三聚氰胺强化引起极大关注，提高了美国人的认识水平。 地方、州和国家的反应机制已经到位，可以快速应对这些情况， 减轻不可预见的后果，同时保护公众和环境健康。不幸的是，回应 每一级的资产都可能很快不堪重负，可能需要激增或冗余的容量。食品 美国食品药品监督管理局食品应急响应计划（FDA FERN）是一个系统， 由联邦和州实验室组成，这些实验室将人员、物资、设备和专业知识 在这些情况下，一起使食品和食品分析。许多实验室都是志愿者 实验室，但14个成员实验室已进入合作协议，现在被称为FERN CAP实验室。阿肯色州卫生部-阿肯色州公共卫生实验室（ADH-PHL） 2009年成为FERN CAP实验室，在过去的1.5年里一直致力于提供必要的 成立了阿肯色州蕨类植物化学实验室。这个新成立的实验室是 路 第三代CAP实验室 ADH-PHL为维护阿肯色州蕨类植物化学实验室提供了坚实的实验室环境。 专用的实验室空间、质量管理系统和额外的增援人员、仪器和空间 在需要时可用。实验室系统通过几个国际公认的 认证机构和整个实验室的工作人员带来了丰富的经验，在四个关键项目领域， GC-MS、LC-MS、ICP-MS和ELISA。ADH-PHL还与管理的其他联邦响应网络合作 由疾病控制中心和环境保护局，即实验室反应 网络（LRN）和环境实验室响应网络（ELRN）。这种内部 协作汇集了沿着具有不同程度专业知识和经验的各种技能组合 以促进互动和程序开发的方式。这些关系对于减轻 人类和环境健康受到威胁的大规模危机。 阿肯色州蕨类植物化学实验室已经达到了100%的目标，确定在第一个2年的合作 协议实验室配备了充足的人员，已经获得、安装并接受了FERN仪器的培训， 与FERN合作伙伴合作，成功验证FERN测试方法，重点是GC-MS，LC-MS，ICP- MS和ELISA已参加并通过FDA提供的所有能力验证，已做出回应 能力，并参加技术和方案会议，其中包括电话会议。这 实验室不断注重改进应急反应和准备工作，并正在与 FDA将寻找加强和扩大FERN响应计划的方法。FERN分析师正在积极评估 FDA提供的各种食品基质分配。这些基质包括奶粉、冻干的 金枪鱼，菠菜，柑橘，菠萝汁，巧克力糖浆，大豆配方奶粉，零食蛋糕，能量 饮料、饮用酸奶、香醋沙拉酱、鲶鱼和烈酒。 这一合作协定的项目计划继续加强应急和备灾工作 通过评估分析能力、交叉培训工作人员以提供额外的快速增援支助、熟练程度 测试和运用各种方法，并参加各种培训论坛，包括会议和 审查方案和技术信息的电话会议。林业发展局提供的培训课程， FERN的其他合作伙伴也将被用来帮助跟上FERN正在使用的最新技术。的 项目计划还包括帮助扩大和加强FERN响应倡议的规定。矩阵评价 分析物扩展研究将继续进行，因为工作人员将接受经过验证的方法的交叉培训和实践。 目前正在探讨定量能力和技术评价，以帮助筹备欧洲环境研究网络 未来的回应和请求。为了帮助简化数据报告， 正在开发处理工具，以帮助加快最后报告。所有这些措施将有利于 通过教育课程和讲座传播新信息。

Project Summary Large scale events like the Deepwater Horizon Oil Rig Explosion of 2010 and infant formula being purposely fortified with melamine in China cause great concern and heighten the level of awareness among Americans. Local, state, and national response mechanisms are in place to quickly respond to these situations and help mitigate unforeseen consequences while protecting public and environmental health. Unfortunately, response assets at every level can quickly become overwhelmed and may require surge or redundant capacity. The Food and Drug Administration Food Emergency Response Program (FDA FERN) is one system in place that is comprised of both federal and state laboratories that bring personnel, supplies, equipment, and expertise together to enable food and food product analyses during these situations. Many laboratories are volunteer laboratories, but 14 member laboratories have entered cooperative agreements and are now referred to as FERN CAP Laboratories. The Arkansas Department of Health-Arkansas Public Health Laboratory (ADH-PHL) became a FERN CAP Laboratory in 2009 and has been working over the past 1.5 years to provide the necessary foundation for launching the Arkansas FERN Chemistry Laboratory. This newly formed laboratory is part of rd the 3 generation of CAP laboratories. ADH-PHL provides a solid laboratory environment for maintaining the Arkansas FERN Chemistry Laboratory. Dedicated laboratory space, quality management systems, and additional surge staff, instrument, and space are available when needs arise. Laboratory systems are accredited through several internationally recognized accrediting authorities, and the entire laboratory staff brings great experience in the four key project areas of GC-MS, LC-MS, ICP-MS, and ELISA. ADH-PHL also partners with other federal response networks managed by the Centers for Disease Control and the Environmental Protection Agency, namely the Laboratory Response Network (LRN) and the Environmental Laboratory Response Network (ELRN), respectively. This internal collaboration brings together a mix of diverse skill sets along with varying degrees of expertise and experience in a way that promotes interaction and program development. These relationships are crucial for mitigating large scale crises where human and environmental health is threatened. The Arkansas FERN Chemistry Laboratory has met 100% of the goals identified in the first 2 year cooperative agreement. The laboratory is fully staffed, has obtained, installed and trained on FERN instrumentation, has worked with FERN partners to successfully validate FERN testing methods focusing on GC-MS, LC-MS, ICP- MS, and ELISA, has participated and passed all proficiency tests provided by FDA, has exercised its response capabilities, and participates in technical and programmatic meetings, which include conference calls. This laboratory continuously focuses to improve emergency response and preparedness efforts and is working with FDA to find ways to enhance and expand FERN response initiatives. FERN analysts are actively evaluating diverse food matrix assignments provided by the FDA. These matrices include powdered milk, freeze-dried tuna, spinach, mandarin oranges, pineapple juice, chocolate syrup, soy-based baby formula, snack cakes, energy drinks, drinkable yogurt, balsamic vinaigrette salad dressing, catfish, and spirits. The project plan for this cooperative agreement continues to bolster emergency response and preparedness initiatives by assessing analytical capacity, cross-training staff to provide additional surge support, proficiency testing and exercising methodologies, and participating in various training forums including meetings and conference calls reviewing programmatic and technical information. Training sessions provided by FDA and other FERN partners will also be used to help stay abreast of the newest technology being used by FERN. The project plan also includes provisions to help expand and enhance FERN response initiatives. Matrix evaluations and analyte extension studies will continue as staff cross-train with and exercise validated methods. Quantitative capabilities and technology evaluations are being explored as a way to help prepare the FERN program for future responses and requests. To help streamline reporting of data, unique data management and processing tools are being developed to help expedite final reporting. All of these measures will benefit the FERN national response program as new information is disseminated through educational courses and lectures.