Clinical Research

临床研究核心（CRC）在未来5年的总体目标是促进和支持 太平洋西北地区的临床艾滋病毒研究：1）招募和转诊艾滋病毒感染者 2）扩大临床研究方案，以提高这些资助研究的生产力， 华盛顿大学艾滋病毒标本库，以支持转化临床和发病机制研究和3） 扩大研究协助和标本采集服务，以协助研究者入组 招募和推荐潜在的研究对象 将由一名专门的研究转诊护士进行，该护士筛选所有在以下地点接受治疗的UW登记研究患者： 华盛顿大学艾滋病诊所，根据研究标准确定合格的患者，并将患者转诊至研究 注册的协调员。华盛顿大学艾滋病毒标本库的扩建将通过以下方式完成： 继续在华盛顿大学艾滋病诊所有针对性地招募艾滋病病毒阳性受试者，并与其他研究小组建立联系 例如CFAR综合系统网络（C-NICS）和坎帕拉艾滋病毒不和谐夫妇研究。 由于化学品审查委员会加强了广告宣传工作， 储存库现已达到足以满足调查人员要求的规模。研究的扩展 由于CRC工作人员的专业知识增加， 空间（检查室）和资源（办公设备、冷冻机、液氮罐）的可用性，以及 加强向区域调查员宣传这些服务。这些活动将紧密联系在一起， CRC向临床流行病学和卫生服务研究、临床逆转录病毒学、发展、 国际和社会行为和预防核心，所有UW CFAR机构（弗雷德哈钦森 癌症中心，西雅图生物医学研究所，华盛顿大学医学院，儿童医院和 区域医疗中心）和其他地方和国家研究小组。这些战略有助于增强 现有的资助研究项目，取决于患者的成功招募和患者的获得 标本这种增值方法直接支持现有的大型、多样化的艾滋病毒研究项目 在华盛顿大学，并提供随时获得艾滋病毒感染者，病人标本， 实施临床研究所需的临床资源。 这些努力推动了地方和国家艾滋病毒调查人员的临床艾滋病毒研究议程， 通过为研究人员提供所需的临床资源， 进行调查。这些资源包括接触潜在的研究对象、患者 研究人员需要使用大量的样本（如血液成分）以及进行研究所需的空间和工具。

The overall objectives of the Clinical Research Core (CRC) over the next 5 years are to promote and support clinical HIV research in the Pacific Northwest region through: 1) Recruitment and referral of HIV-infected persons into clinical research protocols to increase the productivity of these funded studies, 2) Expansion of the UW HIV Specimen Repository to support translational clinical and pathogenesis research and 3) Expansion of the Study Assistance and Specimen Collection Service to aid investigators in the enrollment and implementation of their HIV research protocols Recruitment and referral of potential research subjects will be performed by a dedicated research referral nurse who screens all UW Registry patients cared for at the UW HIV clinics, identifies eligible patients based on study criteria and refers patients to study coordinators for enrollment. Expansion of the UW HIV Specimen Repository will be accomplished by continued, targeted enrollment of HIV+ subjects at the UW HIV clinics and linkage to other research groups such as the CFAR Network of Integrated Systems (C-NICS) and the Kampala HIV discordant couples study. Increased utilization of the Repository will continue due to enhanced CRC advertising efforts and since the Repository has now reached a size sufficient to accommodate investigator requests. Expansion of the Study Assist and Specimen Collection Service will be possible due to the increased expertise of CRC staff, the availability of space (examination room) and resources (office equipment, freezers, liquid nitrogen tanks) and the enhanced advertisement of these services to regional investigators. These activities will tightly link the CRC to the Clinical Epidemiology and Health Services Research, Clinical Retrovirology, Developmental, International and Sociobehavioral and Prevention Cores, all the UW CFAR Institutions (Fred Hutchinson Cancer Center, Seattle Biomedical Research Institute, UW School of Medicine, Children's Hospital and Regional Medical Center) and other local and national research groups. These strategies serve to augment existing funded research programs that depend on successful accrual of patients and access to patient specimens. This value-added approach directly supports the large, diverse HIV research programs that exist at the University of Washington, and provides ready access to HIV infected patients, patient specimens and the clinical resources needed to implement clinical studies. These efforts advance the clinical HIV research agendas of local and national HIV investigators and contribute to the fight against HIV and AIDS by providing researchers with the clinical resources needed to conduct their investigations. These resources include access to potential research subjects, patient specimens (such as blood components) and the space and tools needed to perform their research.