Clinical Research

临床研究核心(CRC)在未来5年的总体目标是促进和支持 太平洋西北地区的艾滋病毒临床研究：1)招募和转介艾滋病毒感染者 临床研究方案，以提高这些资助研究的生产力，2)扩展 华盛顿大学艾滋病毒标本储存库，支持翻译的临床和发病机制研究和3) 扩大学习援助和标本收集服务，以帮助调查人员招生 和执行其艾滋病毒研究方案，招募和转介潜在研究对象 将由一名专门的研究转介护士进行筛查，该护士将筛查所有在 华盛顿大学艾滋病毒诊所根据研究标准确定符合条件的患者，并转介患者进行研究 招生协调员。威斯康星州爱滋病病毒标本资料库的扩充工作将于 在华盛顿大学艾滋病毒诊所继续有针对性地招募艾滋病毒+受试者，并与其他研究小组建立联系 例如CFAR综合系统网络(C-NICS)和坎帕拉艾滋病毒不和谐夫妇研究。 由于加强了儿童权利中心的广告宣传工作，而且由于 储存库现在已达到足以容纳调查人员请求的大小。扩大研究范围 由于儿童权利中心工作人员的专业知识增加，将有可能提供协助和标本收集服务， 提供空间(考场)和资源(办公设备、冰柜、液氮罐)和 加强向区域调查人员宣传这些服务。这些活动将把 临床流行病学和卫生服务研究，临床反病毒学，发育， 国际、社会行为和预防核心，所有UW CFAR机构(弗雷德·哈钦森 癌症中心、西雅图生物医学研究所、华盛顿大学医学院、儿童医院和 区域医学中心)和其他地方和国家研究小组。这些策略有助于增强 现有的资助研究计划取决于患者的成功积累和接触患者的机会 标本。这种增值方法直接支持现有的大型、多样化的艾滋病毒研究项目 在华盛顿大学，并提供对艾滋病毒感染患者、患者样本和 实施临床研究所需的临床资源。 这些努力推进了地方和国家艾滋病毒研究人员的临床艾滋病毒研究议程 通过为研究人员提供所需的临床资源，为抗击艾滋病毒和艾滋病作出贡献 进行他们的调查。这些资源包括访问潜在研究对象、患者 标本(如血液成分)以及进行研究所需的空间和工具。

The overall objectives of the Clinical Research Core (CRC) over the next 5 years are to promote and support clinical HIV research in the Pacific Northwest region through: 1) Recruitment and referral of HIV-infected persons into clinical research protocols to increase the productivity of these funded studies, 2) Expansion of the UW HIV Specimen Repository to support translational clinical and pathogenesis research and 3) Expansion of the Study Assistance and Specimen Collection Service to aid investigators in the enrollment and implementation of their HIV research protocols Recruitment and referral of potential research subjects will be performed by a dedicated research referral nurse who screens all UW Registry patients cared for at the UW HIV clinics, identifies eligible patients based on study criteria and refers patients to study coordinators for enrollment. Expansion of the UW HIV Specimen Repository will be accomplished by continued, targeted enrollment of HIV+ subjects at the UW HIV clinics and linkage to other research groups such as the CFAR Network of Integrated Systems (C-NICS) and the Kampala HIV discordant couples study. Increased utilization of the Repository will continue due to enhanced CRC advertising efforts and since the Repository has now reached a size sufficient to accommodate investigator requests. Expansion of the Study Assist and Specimen Collection Service will be possible due to the increased expertise of CRC staff, the availability of space (examination room) and resources (office equipment, freezers, liquid nitrogen tanks) and the enhanced advertisement of these services to regional investigators. These activities will tightly link the CRC to the Clinical Epidemiology and Health Services Research, Clinical Retrovirology, Developmental, International and Sociobehavioral and Prevention Cores, all the UW CFAR Institutions (Fred Hutchinson Cancer Center, Seattle Biomedical Research Institute, UW School of Medicine, Children's Hospital and Regional Medical Center) and other local and national research groups. These strategies serve to augment existing funded research programs that depend on successful accrual of patients and access to patient specimens. This value-added approach directly supports the large, diverse HIV research programs that exist at the University of Washington, and provides ready access to HIV infected patients, patient specimens and the clinical resources needed to implement clinical studies. These efforts advance the clinical HIV research agendas of local and national HIV investigators and contribute to the fight against HIV and AIDS by providing researchers with the clinical resources needed to conduct their investigations. These resources include access to potential research subjects, patient specimens (such as blood components) and the space and tools needed to perform their research.