Decision Making and Dysregulation Pathways in Adolescents with Parental SUD Histo

描述(由申请人提供)：父母被诊断患有药物滥用障碍(SUD)的儿童表现出更大的吸毒、犯罪和参与危及健康的性行为的风险，这表明不适应的选择过程会带来巨大的社会和公共卫生成本(例如，Kirisci等人，2007年；Reynolds等人，2007年；Tarter等人，L，2002年)。然而，人们对参与这些行为的决定背后的机制知之甚少。我们建议进行假设驱动的次要数据分析，以测试一个概念模型，该模型将父母SUD和儿童调节障碍与不良决策技能的发展和以后生活中健康风险行为的增加联系起来。我们将利用通过教育和药物滥用研究中心(Cedar；NIH#5P50 DA05605)收集的数据，使用其独特的纵向数据集，其中包括经验证的SUD风险可传播责任的衡量标准(Kirisci等人，2009；Vanyukov等人，2009)，一系列基于实验室的决策能力衡量标准(DMC；Parker&Fischhoff，2005)，以及成人对药物滥用、反社会行为和性行为的评估。我们打算在拟议的项目中解决五个主要的研究问题。首先，我们计划确定心理调节的发展轨迹类别。我们将进行分析，以表征从青春期前到成年初期心理调节中个体内部变化的不同模式。其次，我们计划完善DMC的测量，它可以被定义为在做出决策时遵守规范的、合理的标准(Parker&Fischhoff，2005)，通过扩展该结构以涵盖过度冒险和对预期价值的不敏感。第三，我们将研究家庭和育儿变量对随后的DMC和以后生活中的健康风险结果的关联。第四，我们将考察心理调节的发展轨迹对DMC的影响。虽然研究已经将自我调节过程与有利的决策联系起来，但这类研究在很大程度上依赖于横断面设计，因此对从自我调节发展到青少年决策的过程没有任何进展。最后，我们将测试糟糕的DMC在多大程度上可以预测未来的健康风险行为，如吸毒、犯罪行为、高风险性行为和伴侣间暴力。

DESCRIPTION (provided by applicant): Children with a parent diagnosed with substance abuse disorder (SUD) show increased risk for greater drug use, delinquency, and their engagement in health-risking sexual behavior, suggesting maladaptive choice processes with great social and public-health costs (e.g., Kirisci et al., 2007; Reynolds et al., 2007; Tarter et l., 2002). Little is known, however, about the mechanisms that underlie the decisions to engage in these behaviors. We propose to conduct hypothesis-driven secondary data analyses to test a conceptual model that links parental SUD and childhood dysregulation to the development of poor decision-making skills and increased incidence of health-risking behaviors later in life. We will leverage data collected through the Center for Education and Drug Abuse Research (CEDAR; NIH# 5P50 DA05605), using its unique longitudinal dataset that includes validated measures of transmissible liability for SUD risk (Kirisci et al., 2009; Vanyukov et al., 2009), a battery of laboratory-based measures of decision-making competence (DMC; Parker & Fischhoff, 2005), and adult assessments of substance abuse, antisocial behaviors, and sexual behavior. We intend to address five main research questions in the proposed project. First, we plan to identify classes of developmental trajectories for psychological regulation. We will conduct analyses to characterize different patterns of intra-individual change in psychological regulation from preadolescence to emerging adulthood. Second, we plan to refine the measurement of DMC, which can be defined as adherence to normative, rational standards when making decisions (Parker & Fischhoff, 2005) by expanding the construct to encompass excessive risk-taking and insensitivity to expected value. Third, we will examine the associations between family and parenting variables on subsequent DMC and health-risking outcomes later in life. Fourth, we will examine the effects of developmental trajectories of psychological regulation on DMC. While research has linked self-regulative processes to advantageous decision making, such studies have largely relied on cross-sectional designs, and are thus silent on the progression from development of self-regulation to adolescent decision making. Finally, we will test the extent to which poor DMC can predict future health-risking behaviors, such as drug use, criminal behavior, high-risk sexual behavior, and inter-partner violence.