Adolescents with Substance and Conduct Problems: Imaging Callous-Unemotionality

描述（由申请人提供）：本提案由一名早期研究者提交，旨在寻求为期四年的R 01支持，以针对有严重物质和行为问题的青少年患者和青少年对照进行MRI研究。该建议旨在确定神经相关（功能和结构）的冷酷无情（CU）。CU在儿童和青少年时期是可识别的，是一种相对稳定的特征，进入成年期，并与持续的反社会行为问题和物质依赖有关;患有CU，反社会行为问题和物质使用障碍的个体似乎对治疗更有抵抗力。这一建议也将允许搜索的神经相关亚型的药物依赖性发作。我们将招募，完成广泛的诊断面试和形象的主题，而他们发挥阿兰的游戏。该游戏是专为在MRI环境中使用而设计的，在我们的磁铁外试点测试中，它与CU特质分数有很强的关系。

DESCRIPTION (provided by applicant): This proposal, submitted by an early stage investigator, seeks four years of R01 support to conduct an MRI study of adolescent patients with serious substance and conduct problems and adolescent controls. This proposal seeks to identify the neural correlates (both functional and structural) of callous-unemotionality (CU). CU is identifiable in childhood and adolescence, is a relatively stable trait into adulthood, and is linked with persistent antisocial behavior problems and substance dependence; individuals with CU, antisocial behavior problems and substance use disorders appear more resistant to treatment. This proposal will also allow searching for neural correlates of subtypes of adolescent-onset substance dependence. We will recruit, complete extensive diagnostic interviews and image subjects while they play the AlAn's game. That game, which was designed for use in the MRI environment, has demonstrated a strong relationship with CU trait scores in our out-of-magnet pilot testing.