Individualisation of immunosuppressant therapy in renal transplant recipients.

接受肾移植的人需要强效的抗排斥药物。给药很困难。给予相同药物剂量的两个人血液中药物浓度可能有明显不同。如果药物浓度过低，会增加排斥反应的风险。如果剂量过高，会增加药物副作用、感染和癌症的风险。本研究旨在找出为什么不同的人需要不同的剂量，并改进给药方法，从而改善患者的治疗效果。

People who undergo kidney transplantation require potent anti-rejection medications. Dosing is difficult. Two people given the same drug dose can have markedly different blood drug concentrations. If drug concentrations too low, there is an increased risk of rejection. If too high, there is an increased risk of drug side effects, infections and cancer. This study aims to find out why different people need different doses and to improve dosing methods, thereby improving patient outcomes.