Development and Evaluation of a Novel Diagnostic Test for Active Tuberculosis

Nira Pollock，医学博士，博士，目前是贝斯以色列的医学和传染病（ID）讲师 女执事医疗中心（BIDMC）。候选人的长期目标是培养一个独立的病人- 面向研究的职业生涯，重点是开发和评估新的传染性疾病诊断测试 疾病波洛克博士对诊断学的兴趣源于她强大的基础科学和临床相结合的能力。 培训，并专注于她的ID专业。认识到全球结核病病例的增加 艾滋病毒时代的结核病发病率以及目前结核病控制工作的弱点对结核病控制工作的限制， 由于现有的结核病诊断方法，候选人选择将她的研究和临床工作集中在结核病上。下 在两位哈佛大学附属的资深结核病研究人员安东尼奥·坎波斯-内托博士和爱德华· Nardell，她发起了一个有前途的结核病诊断开发项目，并准备了一个多- 专业的职业发展计划，这将使她发展成为一个独立的翻译 研究人员在ID和临床微生物学方面都有非常强的基础。对于她的项目，博士。 波洛克将致力于开发一种新的尿液抗原检测试验，用于诊断活动性结核病。她的目标 是创造一种完全非侵入性的、即时的、快速的测试，这在资源有限的环境中是有用的， 从而为病人护理和结核病控制做出了重大贡献。完成临床前研究后 她将通过将测试整合到一项已建立的结核病临床研究中来评估新的测试， 秘鲁，由卫生伙伴组织管理。这将使她能够评估测试性能，用于常规诊断活动性 成人肺结核，以及获得有关儿童肺结核诊断测试实用性的初步数据 以及用于监测治疗效果。波洛克博士将联合收割机结合她的研究计划， 在哈佛公共卫生学院的临床研究方法的综合教学课程。 最后，她将通过进一步的实践经验，继续发展她在临床微生物学方面的专业知识 在BIDMC微生物实验室，认识到临床微生物实验室提供了一个理想的 应用传染病诊断学研究的环境。 相关性（参见说明）： 该项目的目标是开发一种新的，快速，简单，高准确性的尿液检测诊断， 活动性肺结核（TB）。这项测试可能会极大地改变结核病在世界范围内的诊断方式， 可以帮助防止这种高度传染性和往往致命的疾病的传播。

Nira Pollock, MD, PhD, is currently an instructor of medicine and infectious diseases (ID) at Beth Israel Deaconess Medical Center (BIDMC). The candidate's long-term goal is to develop an independent patient- oriented research career focused on the development and evaluation of new diagnostic tests for infectious diseases. Dr. Pollock's interest in diagnostics emerged from her strong combined basic science and clinical training and was focused by her ID specialization. Recognizing the rise of global tuberculosis (TB) case rates in the era of HIV and the limitations placed on TB control efforts by the weaknesses of currently available TB diagnostics, the candidate has chosen to focus her research and clinical efforts on TB. Under the guidance of two senior Harvard-affiliated TB researchers, Dr. Antonio Campos-Neto and Dr. Edward Nardell, she has initiated a promising TB diagnostic development project and has prepared a multi- disciplinary career development plan which will allow her to develop into an independent translational researcher with an exceptionally strong grounding in both ID and clinical microbiology. For her project, Dr. Pollock will work to develop a new urine antigen detection test for diagnosis of active TB disease. Her goal is to create a fully non-invasive, point-of-care, rapid test which would be useful in resource-limited settings, thereby making a substantial contribution to patient care and TB control. After completing pre-clinical development, she will evaluate the new test by integrating testing into an established clinical study of TB in Peru, run by Partners in Health. This will allow her to assess test performance for routine diagnosis of active pulmonary TB in adults, as well as to gain preliminary data about test utility for diagnosis of TB in children and for monitoring treatment efficacy. Dr. Pollock will combine her research program with a structured, comprehensive didactic curriculum in clinical research methodology at the Harvard School of Public Health. Finally, she will continue to develop her expertise in clinical microbiology through further practical experience in the BIDMC microbiology laboratory, recognizing that the clinical microbiology laboratory provides an ideal setting for applied infectious diseases diagnostics research. RELEVANCE (See instructions): The goal of this project is to develop a new, rapid, simple, and highly accurate urine test for diagnosis of active tuberculosis (TB). This test could dramatically change how TB is diagnosed world-wide, and thus could help prevent the spread of this highly contagious and often deadly disease.