Training Investigators in Neuroimaging and Neuropsychiatry of Movement Disorders

描述（由申请人提供）：本申请面向患者研究（K24）的职业中期研究者奖，计划允许PI将50%的精力用于所描述的指导和研究活动。PI是一名委员会认证的神经精神病学家，在精神病学住院医师后完成了为期两年的运动障碍和神经影像学研究。他贡献了新的神经成像方法，并将其应用于帕金森病和TS的神经精神方面，他目前的研究包括这两个领域的研究，但这一应用主要集中在PI对抽动秽语综合征（TS）的研究。这包括由NIMH和抽动秽语综合症协会资助的正在进行的神经影像学研究，并为该应用提出了新的TS影像学研究。新的研究建立在PI过去的研究基础上，跟进了最近发表的令人兴奋的TS研究成果，并计划与儿童神经病学和儿童精神病学的同事合作，进一步发展一个关于TS的协调研究项目。多年来，PI已经指导了40多名年轻学员，其中许多人是短暂的夏季或学期，但有些人是长期的。在过去的三年里，PI的两名长期临床实习生（一名精神病学住院医生和一名临床神经心理学博士后）因在他的实验室所做的研究和他们的整体职业潜力而获得了美国神经精神病学协会的青年研究者奖。PI现在已经确定了新的医学博士研究员和学生，他们的训练将通过额外的时间来加强，参加本文提出的具体指导活动。该机构作为一个充满活力的神经科学研究中心而闻名，其最近获得的CTSA拨款将进一步支持本提案中的培训和研究活动。该部门承诺免除PI在医学院核心精神病学助理的行政职责，以及住院或咨询联络临床职责，以换取K24奖将支持的指导和以患者为导向的研究机会。简而言之，申请人的指导经历、研究贡献以及近期对TS的研究计划都达到了K24适当支持的最佳时机。

DESCRIPTION (provided by applicant): This application for a Midcareer Investigator Award in Patient-Oriented Research (K24) is planned to allow the PI to devote 50% effort to the mentoring and research activities described. The PI is a board-certified neuropsychiatrist who completed a two-year movement disorders and neuroimaging fellowship after psychiatry residency. He has contributed new neuroimaging methods and applied them to neuropsychiatric aspects of Parkinson disease and TS. His current research includes studies in both these areas, but this application focuses on the PI's research into Tourette syndrome (TS). This includes ongoing neuroimaging studies funded by NIMH and the Tourette Syndrome Association, and new TS imaging studies are proposed for this application. The new studies build on the PI's past research, follow up on exciting leads from recently published TS research, and are planned to further develop a coordinated research program on TS in collaboration with colleagues from child neurology and child psychiatry. The PI has mentored over 40 young trainees over the years, many of them for brief summer or semester stints, but some for longer terms. In the past 3 years, 2 of the PI's longer-term clinical trainees (a psychiatry resident and a clinical neuropsychologist post-doc) have won the American Neuropsychiatric Association's Young Investigator Award for research done in his lab and for their overall career potential. The PI has now identified new M.D. research fellows and students whose training will be enhanced by additional time for the specific mentorship activities proposed herein. The institution is well known as a vibrant center for neuroscience research, and its recently awarded CTSA grant components will further support the training and research activities in this proposal. The department has committed to free the PI from his administrative duties with the medical school core psychiatry clerkship and from inpatient or consultation-liaison clinical duties in exchange for the mentorship and patient-oriented research opportunities that this K24 award will support. In short, the applicant's mentoring experience, research contributions, and near-future plans for research on TS have all arrived at the perfect moment for appropriate support from the K24.