Leukemia Tissue Bank

OSUCCC白血病组织库共享资源（LTBSR）成立于1997年，自成立以来，已从OSU的4，000名同意患者中获得了10，000多份样本。LTBSR成功地促进了白血病基础研究向临床环境的转化，提供了广泛的组织样本库，并附有完整的病理和临床数据， 从白血病患者身上获得的OSUCCC LTBSR的基础设施得到了杰出的机构支持，并由医生科学家和白血病转化研究的资深研究员Guido Marcucci博士指导。他监督着一支训练有素的工作人员，他们在白血病研究方面拥有丰富的经验，提供一系列独特的服务，以支持高质量的 白血病研究LTBSR由一个大型且独特的白血病组织库组成，包括白血病组织和正常组织生殖系DNA，在所有情况下都伴随有完整的病理学、细胞遗传学和临床数据，以便于临床和生物学结果的相关性。此外，所有 有效的白血病组织库管理的基本要素非常完善，包括组织采集活动、最佳实践、标本质量控制、组织储存、初始和随访样本及其病理学和临床信息的采购、数据输入和数据库管理，以及 患者同意和保密。LTBSR利用OSUCCC内部的关键合作伙伴关系， 与其他关键OSUCCC共享资源的有效协调，为OSUCCC的关键研究使命提供基本支持：在血液恶性肿瘤方面进行高质量的基础和临床研究。虽然LTBSR和OSUCCC实体瘤生物储存库和生物样本共享资源在样本采集和样本分配机制上是分开的，但在对OSUCCC研究使命的承诺和患者保密方面，两者遵循相同的操作程序。在OSUCCC内，有效地制定了组织优先排序和分发给大量研究者的程序。管理这种大型白血病组织资源的成功得到了>92%的OSUCCC成员广泛使用这种资源和高影响力出版物（例如，Cell，Cancer Cell，Journal Clinical Oncology，Blood），其中LTBSR发挥了重要作用。

The OSUCCC Leukemia Tissue Bank Shared Resource (LTBSR) was established in 1997 and since its inception has obtained over 10,000 samples procured from 4,000 consented patients at OSU. The LTBSR successfully facilitates translation of basic research in leukemia to the clinical setting by making available an extensive repository of tissue samples, with accompanying complete pathologic and clinical data, procured from leukemia patients. The infrastructure of the OSUCCC LTBSR is supported by outstanding institutional support and is directed by Dr. Guido Marcucci, a physician-scientist and an established senior investigator in translational research in leukemia. He oversees a highly-trained staff with extensive experience in leukemia research that provides a full array of unique services to support high quality leukemia research. The LTBSR consists of a large and unique leukemia tissue repository, including both leukemic tissue and normal tissue germ line DNA, accompanied in all cases with complete pathologic, cytogenetic and clinical data for ready correlation of clinical and biological results. In addition, all the essentials of effective leukemia tissue bank management are very well-developed, including the activities of tissue collection, best practices, quality control of specimens, tissue storage, procurement of initial and follow-up samples and their pathology and clinical information, data entry and database management, and patient consent and confidentiality. The LTBSR leverages key partnerships within .the OSUCCC and efficient coordination with other key OSUCCC Shared Resources, to provide fundamental support of a key research mission of the OSUCCC: to produce high-quality basic and clinical research in hematological malignancy. While separated with regard to the mechanisms of collecting samples and allocation of samples to investigators, the LTBSR and the OSUCCC Biorepository and Biospecimen Shared Resource for solid tumors are governed by the same operational procedures with regard to commitment to the OSUCCC research mission and patients' confidentiality. The procedures for prioritizing and distributing tissue to a large base of investigators within the OSUCCC are effectively in place. The success in managing this large leukemia tissue resource is well-supported by the broad usage of this resource by >92% OSUCCC members and by high-impact publications (e.g.. Cell, Cancer Cell, Journal Clinical Oncology, Blood) by OSUCCC investigators in which the LTBSR has played a significant role.