Meharry Medical College Minority-Based Community Clinical Oncology Program

描述(申请人提供)：本申请是梅赫里医学院(MMC)以少数族裔为基础的社区肿瘤学项目(MBCCOP)的第二次续展，为期9-13年。该计划进行的临床研究方案源自NCI批准的CCOP研究基地，包括东部合作肿瘤组(ECOG)、国家外科辅助乳房计划(NSABP)、妇科肿瘤组(GOG)、德克萨斯大学MD安德森医院(MDA)、美国外科学院肿瘤组(ACOSOG)和国家癌症研究所的临床试验支持单位(CTSU)。2010年，我们增加了ACOSOG作为研究基地，以容纳加入我们MBCCO的社区外科肿瘤学家。所有这些研究基地试验都是关于癌症治疗和癌症预防控制的全国性研究。这些试验中的每一项都有与试验的癌症生物学相关的试验特定的纳入和排除标准。MMC是一所历史悠久的黑人学院和大学(HBCU)，自1876年以来一直在服务，其使命是促进对种族和少数民族的专业培训。MMC的主要临床护理地点是梅哈里的纳什维尔综合医院(NGH)，该医院主要照顾服务不足和贫困的患者，这些患者的种族和少数民族比例很高。作为一家以少数族裔为基础的CCOP，MMC来自田纳西州戴维森县，这是一个基本上由少数族裔组成的地区。在我们的癌症项目中，有色人种患者约占所有血液/肿瘤患者的49%。在MMMC MBCCOP的历史上，非裔美国人患者占试验应计费用的55%，这一比率几乎与我们的总体患者人数相同，表明少数族裔在临床试验中没有偏见或困难。因此，MMC MBCCOP已成功地根据少数族裔受试者在我们医疗中心的患病率进入他们的行列。最近人们注意到，拉美裔患者越来越多地在NGH寻求护理，并开始进入临床试验。女性参加所有试验的比例与她们的疾病患病率成比例，与男性相比，参加乳腺癌和GOG试验的人数要多得多。从历史上看，我们参加临床试验的患者中有60%是女性，这一比例是基于最活跃的乳腺癌治疗试验得出的。在这项申请的报告期内，被评估的非洲裔美国人的流行率进入了NGH的临床试验，所有研究方案的所有临床试验中女性的百分比与我们的总结趋势相似。除了临床试验，MBCCOP还利用其他资金为少数族裔医生建立了1)血液学/肿瘤学奖学金机会，以及2)同行评议资助的针对弱势群体癌症问题的研究努力，其中包括全国性的陈述和最近获得奖励的P20项目，该项目研究弱势群体的治疗后“生存”。

DESCRIPTION (provided by applicant): This application is the second renewal of the Minority-Based Community Clinical Oncology Program (MBCCOP) of Meharry Medical College (MMC) for years 9-13. The program conducts clinical research protocols derived from NCI approved CCOP research bases including the Eastern Cooperative Oncology Group (ECOG), the National Surgical Adjuvant Breast Program (NSABP), the Gynecology Oncology Group (GOG), the University of Texas MD Anderson Hospital (MDA), the American College of Surgery Oncology Group (ACOSOG) and the Clinical Trials Support Unit (CTSU) of the National Cancer Institute. In 2010, we added the ACOSOG as a research base to accommodate a community based surgical oncologist who has joined our MBCCO. All of these research base trials are national studies of cancer treatment and cancer prevention and control. Each of these trials has trial specific inclusion and exclusion criteria that relate to the cancer biology of the trial. MMCis a Historically Black College and University (HBCU) in continuous service since 1876 whose mission is to facilitate the professional training of racial and ethnic minorities. The main clinicl care site of MMC is the Nashville General Hospital at Meharry (NGH) that predominantly cares for underserved and indigent patients with a high prevalence of racial and ethnic minorities. As a minority based CCOP, MMC draws from Davidson County Tennessee, a region that is substantially composed of minorities. In our cancer program, patients of color represent approximately 49% of all hematology/oncology patients presenting for care. Over the history of the MMMC MBCCOP, African- American patients represented 55% of trial accruals, a rate that is virtually identical to our overall patient population and indicates no bias or difficulty enterig minorities onto clinical trials. The MMC MBCCOP therefore has thus been successful to enter minority subjects in proportion to their prevalence in our medical center. It has been recently noted that Hispanic patients are; increasingly seeking care at the NGH and are beginning to be entered onto clinical trials. Women are entered onto all trials in proportion to their disease prevalence with substantially greater numbers entered onto breast cancer and GOG trials compared to men. Historically, 60% of our patients entered onto clinical trials were women which is a skewed rate based on the most active trials treating breast cancer. During the reporting period of this application, the prevalence of African-Americans evaluated entered onto clinical trials at the NGH and the percentage of women on all clinical trials for all research protocols was similar to our summary trends. In addition to the clinical trial efforts, the MBCCOP has leveraged other funds to establish a 1)Hematology/Oncology fellowship opportunity for minority physicians and 2) a peer-reviewed funded research effort in cancer issues of the underserved that includes national presentations and a recently awarded P20 project studying post-treatment "survivorship" of the underserved.