PROTEIN SCIENCE TRANSLATION CORE

创建蛋白质科学翻译核心是为了帮助COBRE的脂质组学和病理学研究人员研究参与脂质代谢和信号传导调节的蛋白质的结构和功能。多年来，核心已经从一个严格的咨询角色转变为一个更积极的角色，在蛋白质科学的各个方面为研究人员提供服务。此外，随着COBRE中的大部分研究继续向临床前和转化科学发展，核心已经成为支持这一努力的关键，可以进行靶点验证和酶靶向转化研究和治疗。自2002年以来，核心已经为超过25名研究人员提供了服务，并研究了35种蛋白质。在COBRE资助的第三阶段，核心的目标是：1）为MUSC的结构和功能表征以及转化研究项目所需的个体研究者生产感兴趣的蛋白质; 2）提供广泛的蛋白质相关专业服务，以满足研究者的需求，并协调中心研究者与MUSC其他现有设施的需求;以及3）通过指导，咨询和推广研讨会提高研究人员对蛋白质科学的理解和能力。总之，这些目标将有助于南卡罗来纳州研究人员的科学成就，他们的研究涉及蛋白质科学的某些方面，从长远来看，这可能有助于开发针对特定疾病的药物。该核心的实用性和受欢迎程度将反过来增强其实现自我维持的前景。

The Protein Science Translation Core was created to assist Investigators of the COBRE in Lipidomics and Pathobiology in studying structures and functions of proteins involved in the regulation of lipid metabolism and signaling. Over the years, the Core has transitioned from a strictly consultative role to a more active role in servicing investigators in various aspects of protein science. Moreover, as the bulk of research in the COBRE continues to evolve towards pre-clinical and translational sciences, the Core has become essential in supporting this effort by enabling studies on target validation and enzyme-targeted translational research and therapeutics. Since 2002, the Core has serviced more than 25 investigators and worked on 35 proteins. The aims of the Core during Phase III of COBRE funding are to: 1) produce proteins of interest for individual investigators that are needed for structural and functional characterization and for translational research programs at MUSC; 2) offer a wide range of protein-related specialty services to suit the needs of investigators and to coordinate the needs of Center investigators with other existing facilities at MUSC; and 3) enhance the understanding and capability of investigators in protein science through mentoring, consultation, and promotional seminars. Taken together, these aims will contribute to the scientific achievement of investigators in South Carolina whose research involve some aspects of protein science, which in the long run could contribute to the development of drugs against specific diseases. The usefulness and popularity of the Core will in turn enhance its prospect in achieving self-sustainability.