Core D - Animal Models and Phenotyping Core

动物模型和表型核心（核心D）有四个主要目标。1)其主要功能是支持 通过提供最先进的设施，支持COBRE-Junior Investigators的研究项目， 开发和表征新的和现有的动物模型的智力能力， 糖尿病和肥胖症的研究。其他目标是：2）为糖尿病患者提供培训和教育， 肥胖中心初级研究人员和成员; 3）开发新的模型，技术和协议， 进一步的糖尿病和肥胖症研究;和，4）成为一个自我维持的实体，支持糖尿病 肥胖中心虽然动物核心将优先满足COBRE-supported 初级研究人员，它还将协助制定新的协议，维护独特的鼠标 线和其他糖尿病和肥胖中心的研究人员创造新的模型。它将提供一个 对动物肥胖、葡萄糖、胰岛素和丙酮酸盐耐受性，体力活动， 体温、食物和水的摄入、氧气消耗和二氧化碳的产生， 评估模型动物在环境挑战下的整体代谢状况，包括高 高脂肪饮食。培训和教育研究人员是动物核心的一个组成部分，它将继续 为中心的初级研究者和成员提供教育。动物中心有训练有素的人员， 反过来教育个别初级研究人员如何正确进行代谢表型测试。的 Animal Core已经并将继续开发研究人员感兴趣的新模型，用于特定的机制。 目的它将通过增加基础设施、设备和 开发最先进的动物模型，并通过建立新的方法，完善测定和使用 在代谢表型分析中有用的统计建模方法。动物核心打算成为一个自我维持的 一个实体，将通过提供基本服务促进中心的长期稳定， 为个人和多PI项目开发新的和独特的功能。

The Animal Models and Phenotyping Core (Core D) has four major goals. 1) Its primary function is to support the research projects of COBRE-supported Junior Investigators by providing state-of-the-art facilities and intellectual capability for the development and characterization of new and existing animal models used in diabetes and obesity research. Other goals are: 2) to provide training and education to Diabetes and Obesity Center junior investigators and members; 3) to develop new models, techniques and protocols to further diabetes and obesity research; and, 4) to become a self-sustaining entity that supports the Diabetes and Obesity Center. While the Animal Core will preferentially address the needs of the COBRE-supported junior investigators, it will also assist in the development of new protocols, maintenance of unique mouse lines and creation of new models for other Diabetes and Obesity Center investigators. It will provide a comprehensive assessment of animal adiposity, glucose, insulin and pyruvate tolerance, physical activity, body temperature, food and water intake, oxygen consumption and carbon dioxide production in order to evaluate the overall metabolic condition ofthe model animal under environmental challenges including high fat diet. Training and educating investigators is an integral function of the Animal Core and it will continue to provide education to Center junior investigators and members. The Animal Core has trained personnel who in turn educate individual junior investigators on how to perform metabolic phenotyping tests correctly. The Animal Core has and will continue to develop new models of interest to investigators for specific mechanistic purposes. It will expand its operations to support future needs by adding infrastructure, equipment and by developing state-of-the-art animal models and by establishing new methods, refining assays and using statistical modeling approaches useful in metabolic phenotyping. The Animal Core intends to become a selfsustaining entity that will promote the long-term stability of the Center by providing essential services and developing new and unique capabilities for individual and multi-PI projects.