Cellular Purification and Analysis Core

获得现代仪器对COBRE的成功至关重要。密歇根州立大学的研究人员已经相当成功地获得了共享的主要研究仪器拨款（主要是美国国家科学基金会），以获得生命和材料科学研究所需的最先进设备（1-6）。具体来说，该COBRE的P.l.和co-Is获得了购买细胞分选、成像和分析工具的奖励，以满足我们生物医学研究人员的需求。目前，密歇根州立大学生物医学研究企业的规模相对较小，没有充分利用其中一些特定仪器或操作这些仪器的技术人员的全部能力。我们预计，随着密歇根州立大学生物医学研究的发展和生物医学研究教师的竞争力增强，这种情况将会改变：这种增长将使COBRE的资金与用户费用相抵消，以帮助维持这些业务。通过资助几个新用户，他们的实验室工作人员和合作者，以及获得导致竞争性资金的初步数据，该COBRE将大大增加这些设施的收入，允许更有效和及时的更换/升级设备，从而使我们的研究人员能够与大型机构的研究人员竞争。这一模式的组成部分已经成功实施，导致研究人员的成功和研究机构的发展（例如成像与分析技术研究所，基因组学研究所，生物技术与生物计算研究所）。从COBRE可持续发展的角度来看，促进“具有互补背景，技能和专业知识的研究人员之间的协作互动努力，并独立竞争外部同行评审中心或项目项目资助支持”，Core C非常重要，因为它为密歇根州立大学的环境提供了成功的模式。利用具有成功商业模式的生产性服务中心的长期成功历史，将确保COBRE初级调查员能够获得资源，将COBRE提案的主题多学科研究重点发展为研究中心。

Access to modern instrumentation is critical to the success of this COBRE. Investigators at MSU have been quite successful in obtaining shared major research instrumentation grants (primarily NSF) to obtain state-of the- art equipment needed for life and materials science research (1-6). Specifically, the P.l. and co-Is for this COBRE have received awards to purchase cell sorting, imaging and analysis tools to meet the needs of our biomedical research faculty. At present, the relatively small size of the biomedical research enterprise at MSU does not utilize the full capacity of several of these particular instruments or of the technical staff who operate them. We expect this situation to change as biomedical research grows at MSU and biomedical research faculty become more competitive: That growth will allow COBRE funding to be offset with user fees to help sustain these operations. By funding several new users, their laboratory staff and collaborators, and the acquisition of preliminary data leading to competitive funding, this COBRE will significantly augment the income of these facilities, allowing more efficient and timely replacements/upgrades of equipment thus allowing our investigators to be competitive with investigators at larger institutions. Components of this model have been successfully implemented, resulting in research faculty success and research institute growth at MSU (e.g. Institute for Imaging & Analytical Technologies, Institute for Genomics, Biotechnology & Biocomputing). From a COBRE sustainability perspective to promote "collaborative interactive efforts among researchers with complementary backgrounds, skills and expertise and to compete independently for external peer-reviewed center or program project grant support", Core C is significant as it provides a successful model to do so in the MSU environment. Taking advantage of the long successful history of a productive service center with a successful business model will ensure that resources are available for the COBRE Junior Investigators to develop the thematic multidisciplinary research focus of this COBRE proposal into a research center.