Collaborative Observational Study of Myopia in Comet Children

描述（由申请人提供）：本提案要求宾夕法尼亚视光学院临床中心继续每年对目前在宾夕法尼亚视光学院中心登记的93名COSMICC参与者（自1997-98年登记以来只有15名受试者失去随访）进行额外5年（总随访14年）的COSMICC2方案检查。从该中心收集的数据将用于解决Chair申请中更详细描述的具体目标，并在此简要总结：1)使用数学函数（Gompertz函数和其他函数）对58%的COSMICC受试者的进行性近视进展进行建模，并基于先前确定的风险因素（年龄，种族，父母近视）建立预测模型和检验假设；2)在这一特征明确的近视队列中，检验与近视进展、稳定和轴向伸长相关的环境危险因素的4个假设；3)检验COSMICC受试者IOP、CCT和黄斑厚度发生近视相关变化的三个相关危险因素的假设。近视的高患病率（占美国成年人口的25%）及其作为公共卫生问题（可导致视力丧失和失明的危险因素）的突出地位强调了增加对潜在进展和最终稳定机制的了解的重要性，以便在未来近视可能被限制在低水平。更好地了解预测近视进展和稳定的因素也将有助于指导干预措施的选择和时机，以及针对那些可能从治疗中获益最多的群体。这个应用程序记录了宾夕法尼亚大学验光学院遵循COSMICC2程序手册的能力，并保留了五年的患者。还提供了文件，证明宾夕法尼亚视光学院拥有人员、设备和设施，可以按照COSMICC2程序手册进行研究。

DESCRIPTION (provided by applicant): This proposal is for the Pennsylvania College of Optometry Clinical Center to continue to annually examine the 93 currently enrolled COSMICC participants (only 15 subjects have been lost to follow-up since enrolled in 1997-98) at the Pennsylvania College of Optometry center for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment. This application documents the Pennsylvania College of Optometry's ability to follow the COSMICC2 Manual of Procedures and to retain patients for five years. Documentation is also provided that the Pennsylvania College of Optometry has the personnel, equipment, and facilities to conduct the study in accordance with the COSMICC2 Manual of Procedures.