Scientific Basis of Iodine-Fluoride Varnish in Preventing Dental Caries

描述（由申请人提供）：几十年来，局部氟化物一直是预防龋齿的主要成分。然而，局部氟化物不足以阻止高危人群蛀牙。第一阶段申请的目的是确定将聚维酮-碘(PVP-I)-5%氟化钠（NaF）组合清漆作为潜在的商业产品用于预防龋齿的技术和科学可行性。这项研究将由小型企业ADP Silver Dental Arrest有限责任公司与华盛顿大学西北减少口腔健康差距中心的经验丰富的研究人员合作进行。Premier Dental Products公司将根据申请人的规格准备清漆，而无需支付任何费用。本研究的具体目的是：(1)证明一种新型聚维酮碘氟化钠清漆具有抗菌活性、氟的生物利用度和牙釉质再矿化能力。(a)使用Castillo及其同事开发的体外模型来确定氟的生物利用度和实验性聚维酮-碘-氟化钠清漆释放的碘；(b)使用Tanzer及其同事的体外模型，根据Eliopoulos和Moellering标准评估氟化钠和聚维酮碘对变形链球菌的加性（无影响）、潜在协同作用或潜在拮抗作用；(c)略微修改Featherstone实验室pH循环模型来测试再矿化。(2)评价新型聚维酮碘氟化钠清漆的美学和感官性能。龋齿研究人员提出了一些策略，除了局部氟化物主要是牙釉质再矿化外，还建议将防腐剂与局部氟化物结合使用，以减少或消除口腔致龋细菌库。聚维酮碘是fda批准并广泛使用的杀菌防腐剂。对于口腔菌群，碘对链球菌有优先的活性。此外，碘的有效性可能会持续长达6个月。

DESCRIPTION (provided by applicant): Topical fluorides have been the mainstay in the prevention of dental caries for decades. However, topical fluoride alone is not enough to thwart tooth decay in high-risk populations. The purpose of this Phase I application is to determine the technical and scientific feasibility of using a combination povidone-iodine (PVP-I)-5% sodium fluoride (NaF) varnish as a potential commercial product to prevent dental caries. The research will be conducted by the small business firm ADP Silver Dental Arrest, LLC, in collaboration with experienced researchers at the University of Washington Northwest Center to Reduce Oral Health Disparities. The Premier Dental Products Company will prepare the varnish to the specifications of the applicant at no cost to the grant. The Specific Aims of this Phase I SBIR are to: (1) Demonstrate that a new povidone iodine-sodium fluoride varnish has antimicrobial activity and fluoride bioavailability and enamel remineralization ability. (a) Use the in vitro moel developed by Castillo and colleagues to determine the bioavailability of fluoride and iodine release from an experimental povidone-iodine- sodium fluoride varnish; (b) Use an in vitro model of Tanzer and colleagues to assess the additive (indifferent), potentially synergistic, or potentially antagonistic effects of sodium fluoride and povidone-iodine against Streptococcus mutans using the criteria of Eliopoulos and Moellering; (c) Use a slight modification the Featherstone laboratory pH cycling model to test remineralization. (2) Assess the esthetic and organoleptic properties of the new povidone iodine-sodium fluoride varnish. Caries researchers for sometime have suggested strategies that combine an antiseptic with topical fluoride to reduce or eliminate the oral cariogenic bacteria reservoir in addition to topical fluoride which primarily remineralizes teeth enamel. Povidone-iodine is an FDA-approved and widely used bactericidal antiseptic. For the oral flora, iodine has preferential activities against streptococcl species. Moreover, iodine's effectiveness may last as long as six months.