Lifestyle Factors and Lymphoma: An Asia Cohort Consortium Pooling Project

描述（由申请人提供）：非霍奇金淋巴瘤（NHL）是美国成人中最常见的造血系统癌症。在高加索人群中进行的研究表明，较高的体重和吸烟可能会增加风险，而饮酒可能会降低风险。然而，目前尚不清楚亚洲人群是否存在相同的关系，因为亚洲人群的发病率历史上一直低于高加索人。鉴于亚洲许多国家和美国移民中肥胖和吸烟的患病率不断上升，迫切需要澄清这些可改变因素在NHL风险中的潜在作用。本研究的目的是调查亚洲人群中淋巴瘤死亡与体重、吸烟和饮酒之间的关系。为了实现这些目标，我们将使用来自亚洲队列联盟的数据进行队列分析;包括17个队列，超过870，000名参与者和686例记录的NHL死亡。关于体重、吸烟和饮酒的数据已经统一。还从每个队列中获得了当前提案的NHL死亡和人时间数据。我们将使用考克斯比例风险回归模型研究NHL死亡与体重、吸烟和饮酒之间的关系。将使用两阶段方法分析汇总数据，比较固定效应模型与随机效应模型的风险估计值，以评估异质性的影响。利用亚洲队列联盟的现有数据，拟议的研究对于澄清体重，吸烟和饮酒与NHL风险之间的关系以及将研究结果扩展到亚洲人群（美国增长最快的种族群体之一）具有极高的成本效益。

DESCRIPTION (provided by applicant): Non-Hodgkin lymphoma (NHL) is the most common hematopoietic cancer among adults in the United States. Studies conducted in Caucasian populations suggested that a higher body mass and smoking may increase risk while alcohol use may lower the risk. However, it is not known whether the same relationships exist in Asian populations for which incidence rates historically have been lower than Caucasians. Given the rising prevalence of obesity and cigarette smoking in many countries in Asia and immigrants in the US, there exists an urgent need to clarify the potential role of these modifiable factors in th NHL risk. The aims of this research are to investigate the associations between deaths from lymphoma and body mass, smoking, and alcohol use in Asian populations. To accomplish these aims, we will conduct a cohort analysis using data from the Asia Cohort Consortium; consisting of 17 cohorts with over 870,000 participants and 686 recorded NHL deaths. Data on body mass, tobacco smoking, and alcohol use have already been harmonized. Data on NHL deaths and person time for the current proposal have also been obtained from each cohort. We will examine the association between deaths from NHL and body mass, smoking, and alcohol consumption using Cox proportional hazard regression models. A two- stage method for analysis of pooled data will be used to compare the risk estimates from fixed- effects models with those from random-effects models to assess the effect of heterogeneity. Using existing data from the Asia Cohort Consortium, the proposed study is extremely cost-effective for clarifying the relationship between body mass, smoking, and alcohol use and risk of NHL and extending findings to the Asian populations, one of the fastest growing ethnic groups in the United States.