Fundamental Mechanobiology of Tumor Progression

PS-OC倡议的目标是共同促进我们对塑造和管理癌症及其行为的各个层次出现的物理规律和原理的理解。PS-OCS将汇集来自物理、癌症生物学、物理化学、数学和工程领域的专家团队，以组装和开发使团队研究汇聚所需的基础设施、能力、研究计划和网络。自然科学与癌症生物学。PS-OCS将单独和共同支持和培育一种新的跨学科环境和研究，以：(1)开创并测试以新的、非传统的物理科学为基础的了解和控制癌症的新方法；(2)产生正交的物理测量集并将其与现有的癌症知识相结合；以及(3)开发和评估理论物理方法，以提供对癌症的全面和动态的图像。最终，通过协调的、替代的、跨网络的开发和测试创新的、可能是非传统的癌症过程方法，PS-OCS将催化和产生新的知识体系和癌症研究领域，以确定和定义在癌症过程中各级运作的关键方面“物理、化学和工程”。我们聚集了来自物理和生命科学的不同领域的研究人员，以参与该中心。这包括五个湾区组织，它们在物理科学、工程以及癌症研究和治疗方面拥有全球公认和长期的能力和兴趣。我们还从2个外部机构招募了临床研究人员，以补充现有的专业知识，并扩大我们项目的翻译范围。

The goal of the PS-OC initiative is to collectively advance our understanding of the physical laws and principles that shape and govern the emergence of cancer and its behavior at ail scales. The PS-OCs will bring together expert teams from the fields of physics, cancer biology, physical chemistry, mathematics, and engineering to assemble and develop the infrastructure, capabilities, research programs, and the Network required to enable team research converging. the physical sciences with cancer biology. PS-OCs, individually and together, will support and nurture a new trans-disciplinary environment and research that: (1) originates and tests novel, non-traditional physical-sciences based approaches to understanding and controlling cancer; (2) generates orthogonal sets of physical measurements and integrates them with existing knowledge of cancer; and (3) develops and evaluates theoretical physics approaches to provide a comprehensive and dynamic picture of cancer. Ultimately, through coordinated, alternative, trans-Network development and testing of innovative, perhaps non-traditional, approaches to cancer processes, PS-OCs will catalyze and generate new bodies of knowledge and fields of cancer study that identify and define the critical aspects "physics, chemistry, and engineering" that operate at all levels in cancer processes. We are bringing together a cross section of investigators from the Physical and Life Sciences to participate in the center. This includes five Bay Area organizations with globally recognized and long-standing capabilities and interests in the physical sciences, engineering, and cancer research and treatment. We have also recruited clinical investigators from 2 outside institutions to compliment existing expertise and to extend the translational scope of our projects.