Inflammatory mediators of liver injury in chronic hepatitis C

目前，慢性丙型肝炎和肥胖引起的肝病是一个主要的健康问题。总体而言，澳大利亚约50%的慢性丙型肝炎患者患有肥胖症，这些患者迅速发展为肝功能衰竭的风险显著增加。现在人们认识到，脂肪衍生因子在调节炎症反应中起着重要作用。这项赠款提案旨在深入了解肝脏和脂肪衍生的炎症因子如何相互作用，促进慢性丙型肝炎和肥胖症患者肝脏损害的增加。

Presently, liver disease from chronic hepatitis C and obesity represents a major health problem. Overall, approximately 50% of Australians with chronic hepatitis C are obese and these patients are at significantly increased risk of rapidly progressing to liver failure. It is now recognized that fat derived factors play an important role in regulating inflammatory responses. This grant proposal aims to gain insight into how liver and fat derived inflammatory factors interact to promote increased liver damage in chronic hepatitis C and obesity.