Aspen Lung Conference: The Lung Microbiome: A New Frontier in Pulmonary Medicine

描述（由申请人提供）：第56届Thomas L. Petty年度肺病会议的主题是“肺微生物组：肺医学的新前沿”。会议强调基础科学、转化科学和临床科学的整合，将重点讨论健康状态和疾病中肺部微生物组及其与环境、遗传和饮食的相互作用。作为一个不断暴露于环境和体循环的器官，肺部遇到的吸入颗粒肯定不是无菌的，免疫系统必须区分自我和非自我。肺部是否有独特的微生物种群占据特定的生态位仍然是一个有争议的话题。2013年阿斯彭肺会议将检查和讨论微生物群从研究良好的粘膜表面（肠道，皮肤）和可能的相互作用与肺粘膜。还有一些问题需要回答，这些问题将在本次会议上讨论，包括：肺和肠道之间是否存在串扰？是否有细菌从肠道转移到肺部？肺部微生物群是在出生时建立的吗？它反映的是母亲阴道的微生物群还是上呼吸道的微生物群？与宿主的相互作用主要是通过先天免疫系统还是适应性免疫系统？本次会议的总体目标是：1)促进肺部研究科学家、医生和基础科学家之间的对话和交流，他们的主要重点是鉴定和测试各种解剖部位的微生物组；2)在微生物学家和对肺部病理生物学感兴趣的研究人员之间发起对话。3)教育肺科学家关于肺微生物群与肺外各部位之间潜在的交叉对话4)为领先的临床医生和研究人员提供一个国际论坛，以交流有关肺微生物群及其与其他解剖部位微生物群的关系的想法5)填补关于是否存在独特肺微生物群的认识的知识空白6)激发新的视角和进一步研究肺微生物群在健康和健康方面的作用确定肺部微生物组的改变是否以及如何导致或改变呼吸系统疾病7)创造一个能引起学员持续兴趣的环境

DESCRIPTION (provided by applicant): The theme of the 56th Annual Thomas L. Petty Lung Conference is "The Lung Microbiome: A New Frontier in Pulmonary Medicine." Emphasizing the integration of basic, translational and clinical sciences, the meeting will focus upon the lung microbiome and its interactions with the environment, genetics and diet in healthy states and disease. As an organ that is constantly exposed to the environment as well as the systemic circulation, the lung encounters inhaled particles that are certainly not sterile and an immune system that has to differentiate between self and non-self. Whether the lung has unique microbial populations that occupy specific niches is still a subject for debate. The 2013 Aspen Lung Conference will examine and discuss microbiota from well- studied mucosal surfaces (gut, skin) and the likely interplay with lung mucosa. Questions that remain to be answered and that will be addressed in this conference include: Is there crosstalk between the lung and the gut? Is there bacterial translocation from gut to lung? Is the lung microbiome established at birth? Does it reflect the mother's vaginal microbiome or is it a reflection of the microbiome in the upper airways? Are the interactions with the host primarily through the innate or adaptive immune systems? The overall objectives of this conference are: 1) To stimulate conversations and cross-pollination between pulmonary research scientists and physicians and basic scientists whose main focus is the identification and testing of microbiomes in various anatomical sites 2) To initiate a dialogue between microbiologists and researchers interested in pulmonary pathobiology. 3) To educate pulmonary scientists about the potential cross-talk between the microbiomes of the lung and various extrapulmonary sites 4) Provide an international forum for leading clinicians and researchers to exchange ideas relating to lung microbiome and its relationship to microbiomes at other anatomical sites 5) Fill a knowledge gap in the understanding of whether there is a unique lung microbiome 6) Stimulate new perspectives and further research in pulmonary microbiota in health and disease Determine if and how the alteration in the lung microbiome leads to or alters respiratory disorders 7) To create an environment that will lead to sustained interest among trainees