Genetic and Neural Complexity in Psychiatry

摘要 精神遗传学领域的最新进展带来了兴奋和紧迫感，以明智地设想和设计下一步，以告知精神疾病的神经生物学，并制定预防，早期干预或治疗的策略。关于“精神病学中的遗传和神经复杂性”会议的主要目标是促进对精神病学研究未来的讨论，因为它是由遗传学的最新进展和神经科学中新兴的概念和方法形成的。这次会议将汇集专家，开启遗传学家和神经科学家之间的对话，允许直接翻译和快速应用最近的发现。在拟议的三年两次的系列会议中，计划的第一次会议将重点关注深度测序方法，这将有助于发现罕见的高渗透突变，以及旨在了解其对基因功能影响的方法，包括小鼠模型的产生。它还将解决新兴的重编程技术，允许从携带特定罕见突变的患者中开发细胞模型，以及研究其他动物物种的利弊，特别强调非人类灵长类动物。最后，它将突出和讨论新的方法来破译电路和通信的疾病大脑。

Abstract Recent advances in the field of psychiatric genetics have brought about excitement and urgency to envision and design intelligently the next steps in order to inform the neurobiology of the psychiatric disorders and develop strategies for prevention, early intervention, or treatment. The primary goal of the meeting on the "Genetic and Neural Complexity in Psychiatry" is to facilitate a discussion on the future of research in Psychiatry as it is shaped by the recent advances in genetics and newly emerging concepts and approaches in neuroscience. This meeting will bring together experts and open a dialogue between geneticists and neuroscientists allowing direct translation and speedy application of recent findings. The first planned meeting in the proposed series of 3 bi-annual meetings, will focus on deep sequencing approaches, which will allow discovery of rare, highly penetrant mutations, as well as on approaches designed to understand their impact on gene function, including the generation of mouse models. It will also address emerging reprogramming technologies that allow development of cellular models from patients carrying specific rare mutations as well as the pros and cons of studying additional animal species with particular emphasis on non-human primates. Finally, it will highlight and discuss novel approaches to decipher circuitry and communication in the disease brain.