精炼组合直肠制剂的非临床策略-猫眼课题宝

精炼组合直肠制剂的非临床策略

批准号：

8722088

负责人：

Charlene Dezzutti

金额：

$15.9万

依托单位：

MAGEE-WOMEN'S RES INST AND FOUNDATION

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

已结题

起止时间：

至 2016-08-31

来源：

https://reporter.nih.gov/project-details/8722088

关键词：

AIDS prevention Address Affect Africa South of the Sahara Agreement Algorithms Anal Sex Anti-Retroviral Agents Anus Biological Assay Biopsy CCR5 gene CXCR4 gene Cell Line Cells Clinic Clinical Clinical Research Clinical Trials Coitus Colon Colorectal Confocal Microscopy Controlled Environment Data Dendrimers Developed Countries Development Disease Drug Antagonism Drug Formulations Drug Kinetics Ensure Epidemic Epithelial Epithelial Cells Epithelium Evaluation Excision Future Gastrointestinal tract structure Gel Generations HIV HIV Infections HIV-1 Histology Hour Human In Vitro Incidence Infection Inhibitory Concentration 50 Intravaginal Administration Laboratories Lectin Local Microbicides Measurement Measures Methods Modality Operative Surgical Procedures Outcome Pharmaceutical Preparations Phase Preparation Prevention Preventive Probability Production Recording of previous events Rectum Resected Resistance SPL7013 Safety Seminal Plasma Seminal fluid Sex Behavior Sexual Transmission Source Submucosa System Testing Tight Junctions Time Tissues Toxic effect UC 781 Vagina Viral Virus Work base cellulose sulfate condoms cost design drug candidate experience human tissue improved inhibitor/antagonist interest killings microbicide novel strategies patient safety prevent programs receptor rectal rectal microbicide safety testing screening stability testing success transmission process vaginal microbicide

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中文摘要

翻译

面对现有的艾滋病毒-1流行病，需要有效混合预防方式，以开始减少艾滋病毒-1的发病率。这包括局部使用杀菌剂。这些产品可以用来防止HIV-1的性传播；包括接受性肛交。本U19项目1“直肠联合制剂精制的非临床策略”将致力于开发一种安全有效的直肠杀微生物剂。到目前为止，2b期临床试验

英文摘要

In the face of the existing HIV-1 epidemic, an effective mix of prevention modalities are needed to begin to reduce the incidence of HIV-1. This includes the used of topical microbicides. These are products that would be used to prevent the sexual transmission of HIV-1; including receptive anal intercourse. Project 1, Nonclinical Strategies for Refining Combination Rectal Formulations, of this U19 will strive to ensure that a safe and effective rectal microbicide will be developed. To date, the Phase 2b trials of

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