Piezoelectric Pump to supply Ventricular Assist Device for Fontan Patients

描述（由申请人提供）：先天性心血管缺陷，特别是单心室异常，是出生缺陷婴儿最常见的死亡原因。即使在通过Fontan手术改变单心室循环后，这些患者的循环仍然依赖于血液被动地通过肺部流动。因此，这组患者持续面临丰坦衰竭及其后果的风险。因此，需要一种紧凑的方法来驱动可植入的心室辅助装置，用于重新激活这些患者的血流。在过去的十年中，我们的团队在频率整流概念方面取得了进展，已经产生了用于变形飞机结构的新型紧凑型压电液压泵。虽然它们代表了航空航天领域的重大进步，但它们尚未被视为机械循环支持装置的驱动因素。我们的假设是，这些新的大功率装置可以有效地用作方丹循环的微型辅助装置驱动器。我们建议开发和评估一种新型压电液压泵驱动器，为Fontan循环患者重新激活血液流向肺部。我们的假设是，压电液压技术代表了一种为儿童和成人Fontan患者构建小型化心室辅助装置驱动器的新方法。本研究的重点是通过实验证明压电泵将能量传递到Fontan循环并辅助Fontan患者血液流动的能力。我们计划利用新的压电液压泵来驱动商业短期循环支撑装置和加州大学洛杉矶分校制造的长期植入式装置。该装置将在体外进行表征，以证明该系统可以在模拟Fontan流体回路中增加肺循环中的流体流量，同时降低全身静脉压力。到目前为止，没有足够小的机械辅助装置驱动程序供儿科患者使用。所提议的努力不仅将提供机会实现一种独特的装置来帮助

DESCRIPTION (provided by applicant): Congenital cardiovascular defects, specifically single ventricle abnormalities, constitute the most common cause of death among infants born with birth defects. Even after surgically rerouting the single ventricle circulation via the Fontan procedure, the circulation in these patients relies on blood flowing passively through the lungs. Thus, this group of patients is continually at risk for Fontan failure and its consequences. Thus, there is a need for a compact method to drive implantable ventricular assist devices used to re-energize blood flow in these patients. Over the last decade, our team has made advances in frequency rectification concepts that have yielded novel compact piezoelectric hydraulic pumps for morphing aircraft structures. While representing a significant advancement in aerospace, they have yet to be considered as drivers for mechanical circulatory support devices. It is our hypothesis that these new high power devices can be effectively used as miniature assist device driver for Fontan circulation. We propose to develop and evaluate a novel piezoelectric hydraulic pump driver tailored to re-energize blood flow to the lungs for patients with the Fontan circulation. It is our hypothesis that the piezohydraulic technology represents a novel approach to construct a miniaturized ventricular assist device driver for both pediatric and adult Fontan patients. The focus of this research is to experimentally demonstrate the ability of a piezoelectri pump to transfer power to the Fontan circulation and assist blood flow in Fontan patients. We plan to utilize the new piezoelectric hydraulic pump to drive a commercial short term circulatory support device and also a long term implantable device fabricated at UCLA. This device will be characterized in vitro to demonstrate that the system can increase fluid flow through the pulmonary circulation while reducing systemic venous pressure in a mock Fontan fluidic circuit. To date, mechanical assist device drivers small enough for pediatric patients are non-existent. The proposed effort will not only provide the opportunity for realization of a unique device to aid patients with the Fontan circulation, but it will also provide an outline for the use of compact hih power density piezoelectric devices for use as mechanical circulatory support drivers