Sexual Distress and Body Image Distress in Younger Breast Cancer Survivors

描述（由申请人提供）：本研究的目的是研究正念减压对年轻乳腺癌幸存者的性痛苦症状和身体形象相关痛苦的影响。与性相关的问题在年轻的乳腺癌幸存者中很普遍，并且经常在手术和辅助治疗后导致这一人群的性困扰和身体形象问题。该项目将建立在MBSR乳腺癌幸存者症状集群试验（1R01CA131080）的资源和优势之上，该试验由本次NRSA申请的发起人Lengacher博士进行，并将补充Lengacher博士的研究目标。对于这一博士前NRSA，将从这些年轻的临床人群中获得更多的证据，这些人群是赞助商的R01研究的受试者，以确定：(1)治疗后过渡期年轻乳腺癌女性的心理和生理困扰水平；(2)正念减压-乳腺癌（MBSR (BC)）减压项目在改善与性相关的痛苦（即性痛苦和身体形象相关的痛苦）方面的有效程度；(3)与老年乳腺癌幸存者相比，这一亚群年轻患者是否从MBSR （BC）中获益最多。为了帮助了解影响这一人群生活质量的性困扰和身体形象相关困扰的程度，将采取两阶段的研究方法。首先，在第一阶段，将对参与R01研究的年龄21-54岁的年轻乳腺癌幸存者的基线数据进行二次数据分析。第一阶段的具体目标是通过对R01研究乳腺癌幸存者MBSR症状聚类试验收集的数据进行二次分析，评估年轻女性的痛苦水平，包括抑郁、焦虑、对复发的恐惧、心理和身体痛苦以及生活质量。在第二阶段，一项试点研究（也是论文研究的重点）将在赞助商R01资助的80名乳腺癌幸存者亚组中实施。本初步研究的目的是：1)评估MBSR （BC）项目在改善与性困扰和身体形象相关的困扰以及心理、身体症状和生活质量方面的效果；2)评估MBSR （BC）项目所取得的积极效果是否被基线测量的特定患者特征所改变。由此产生的数据将有助于更好地了解性痛苦和与身体形象有关的痛苦，为今后预防疾病和改善因乳腺癌治疗而遭受性痛苦和与身体形象有关的痛苦的妇女的生活质量奠定基础。预计这项研究的结果将提供进一步的发展或适应特定的干预措施，以改善症状管理，支持和教育妇女在这一人群

DESCRIPTION (provided by applicant): The purpose of this research is to examine the impact of MBSR on the symptoms of sexual distress and body image related distress in younger breast cancer survivors. Problems related to sexuality in younger breast cancer survivors are prevalent and often reported following surgical and adjuvant treatment leading to sexual distress and body image issues in this population. This project will build upon the resources and strengths of the MBSR Symptom Cluster Trial for Breast Cancer Survivors, 1R01CA131080, which is being conducted by Dr. Lengacher, the sponsor of this NRSA application, and will complement the goals of Dr. Lengacher's study. For this Pre-doctoral NRSA, additional evidence in this younger clinical population who are subjects in the Sponsor's R01 study will be obtained to determine: (1) levels of psychological and physical distress in younger women with breast cancer in transition after treatment; (2) the extent to which the Mindfulness-Based Stress Reduction-Breast Cancer (MBSR (BC)) as a stress reducing program is efficacious in improving distress related to sexuality, i.e. sexual distress and body image related distress; and (3) if this subgrou of younger patients derive the most benefit from MBSR (BC) compared to older breast cancer survivors. To contribute to the limited knowledge regarding the extent of sexual distress and body image related distress as they impact the quality of life in this population, a two-phase study approach will be taken. First, in Phase 1, a secondary data analysis will be performed on baseline data of the younger breast cancer survivors, age 21-54 participating in the R01 study. The specific aim for Phase 1 is to assess the levels of distress among young women including depression, anxiety, fear of recurrence, psychological and physical distress, and quality of life through secondary analysis of data collected in the R01 study MBSR Symptom Cluster Trial for Breast Cancer Survivors. For Phase 2,a pilot study, also the focus of the dissertation research, will be implemented among a subgroup of 80 breast cancer survivors from the Sponsor's R01 grant. The aims for this pilot study will be to 1) evaluate the efficacy of the MBSR (BC) program in improving sexual distress and body image related distress along with psychological, physical symptoms and quality of life and 2) evaluate whether positive effects achieved from the MBSR (BC) program are modified by specific patient characteristics measured at baseline. Resulting data will provide a better understanding of sexual distress and body image related distress, providing a foundation for future disease prevention and improved quality of life in women experiencing sexual distress and body image related distress as a result of their breast cancer treatment. It is anticipated that the findings of this study will provide further development or adaptation of specific interventions appropriate for improved symptom management, support, and education for women in this population