Personal Perspective and Provider Communication of Genomic Risk for T2DM

描述(由申请人提供)：该研究计划的长期目标是通过设计策略来交流复杂的遗传信息，以帮助个人、家庭和临床医生利用遗传/基因组信息影响积极的健康行为改变，从而转化科学进步。本研究的目的是阐明在一组与2型糖尿病有一级亲属的个体中，遗传/基因组风险感知的个人化过程。本研究提出了四个具体目标：1.在有家族史者的情况下，比较文化/种族差异对个人患2型糖尿病风险的解释。2.找出具有T2 DM家族风险的人对遗传风险和遗传机制的误解。3.研究在有2型糖尿病家族史的个体中，对风险、基因组素养和数字概率低估的解释是如何聚集在一起的。4.探讨T2 DM的两种降低危险行为(低脂饮食和运动)与T2 DM家族史、T2 DM认知风险、疾病致病模式、基因组素养、算术能力、是否担心T2 DM发病的关系。将使用混合方法进行一项单一研究，以解决所有四个具体目标。250名成年人将从美国中西部的一个州招募。本研究将从定性和定量两个角度探讨2型糖尿病患者家庭风险认知的个性化过程。将使用主题分析和聚类分析来分析定性数据。对量化数据进行相关分析和回归分析。方法三角测量揭示了同一现象的互补方面，以便于更深入地了解，并找出数据的分歧点，以便更好地理解复杂疾病风险增加的人，由于特定疾病的阳性家族史，如何理解和管理行为以降低他们的疾病风险。了解一个人的信念可能会促进与医疗保健提供者的有效合作，并改善降低风险的教育。

DESCRIPTION (provided by applicant): The long-term objectives of this program of research is to translate scientific advances through devising strategies to communicate complex genetic information to assist individuals, families, and clinicians in the use of genetic/genomic information to affect positive health behavior change. The objective of this study is to elucidate the personalizing process for genetic/genomic risk perception in a diverse group of individuals who have a first degree relative with type 2 diabetes mellitus. Four specific aims are proposed: 1. Compare cultural/ethnic variations in individuals' explanations of their personal risk for T2DM given a positive family history. 2. Identify misunderstandings of risk and genetic mechanisms of inheritance communicated by people who have a familial risk of T2DM. 3. Examine how explanations of risk, genomic literacy and understating of numeric probabilities cluster in individuals with a family history of T2DM. 4. Explore the relationship among two T2DM risk reducing behaviors (following low fat diet and exercising) and family history of T2DM, perceived risk of T2DM, causation model of illness, genomic literacy, numeracy, and worry about developing T2DM. A single study using mixed methods will be used to address all four specific aims. Two hundred and fifty adults will be recruited from across a Midwestern state in the USA. Both qualitative and quantitative data sources will be used to explore the personalizing process of family risk perception in T2DM. Thematic and cluster analysis will used to analyze the qualitative data. Correlation and regression will be used to analyze the quantitative data. Methods triangulation reveals complementary aspects of the same phenomenon to facilitate a deeper understanding, and identify points where the data diverge in order to better understanding of how people at increased risk for complex diseases, due the positive family history for the particular disease, come to understand and manage behaviors to reduce their risk for disease. Understanding a person's beliefs may facilitate effective collaboration with healthcare providers, and improve risk reduction education.