Administrative Core

拟议的P30症状管理生物行为方法卓越中心（CEBASM）建立在我们成功的P20生物行为临床研究探索中心（CBCR，P20 NR 008988，McCain，PI）的基础上。CEBASM将利用通过CBCR开发的与症状管理和生物行为结果有关的协同作用，以及为以下目的收集的资源和开发的系统： 该中心，并将其扩展到生物行为模型，方法和分析的高级应用，旨在了解生物行为机制，干预措施和与症状管理相关的结果，重点是疲劳。Pickler、Grap、里昂、McCain、Munro和Elswick博士为该卓越中心提供了研究基础，他们共同并在自己的工作中显著推进了早产儿、癌症患者和重症患者的生物行为科学和/或症状管理。这组资深研究人员为P20中心的成功提供了科学和行政基础。他们的专业知识指导了这里提出的项目，并将有助于培养未来专注于症状管理的生物行为科学家。P30卓越中心的具体目标是 1.通过集中研究资源和基础设施，以症状管理为重点进行生物行为临床研究，扩大科学家进行护理研究的生物行为研究能力; 2.在不同人群中推进症状管理的生物行为方法，包括疲劳及其相关症状; 3.促进独立的生物行为项目的发展和扩展，研究人员发起的生物行为研究有一个共同的主题疲劳; 4.建立一个成熟的环境，可持续的生物行为研究的症状管理，是临床重点和跨学科的性质。 拟议的P30卓越中心的目标与NINR战略计划中确定的几个机会领域相关，包括：1）开发或改进与症状群相关的生物行为方法，措施和干预策略; 2）开发技术以促进症状的早期检测; 3）描述症状的致病机制; 4）开发和测试干预措施，以改善患者对离散和共病条件下的症状和症状群的反应和适应; 5）设计策略以改善疾病轨迹上的症状管理; 6）通过了解疾病表现和在服务不足的人群中测试创新干预措施，消除健康差距。此外，拟议的中心将满足NINR的科学进步战略，整合生物学和行为学，并为下一代护理科学家做准备。来自该中心的研究将描述症状管理的生物行为机制，重点是疲劳作为生物行为临床研究和项目的常见症状。中心的项目将针对非洲裔美国青少年、患有与镰状细胞病相关的疲劳的成年人和患有乳腺癌的妇女，她们经历疲劳及其导致认知功能障碍的相关症状。研究还将测试以生物行为为重点的干预措施，以改善怀孕的非洲裔美国妇女，纤维肌痛妇女和心血管风险妇女的结局。最终，中心的研究将导致进一步的干预措施，以改善与复杂症状星座相关的患者结局，包括疲劳的常见症状。 拟建中心将：通过以下方式加强VCU的研究基础设施：（a）扩大和定向资源，以促进和支持关注生物行为机制、管理和复杂症状群结果的研究，包括常见的疲劳症状;（B）扩大对不同人群症状群的生物行为理解;（c）增加参与跨学科研究的初级研究人员的机会，以利用生物行为模型和方法进一步制定研究方案;以及（d）通过建立一个积极的、跨学科的合作基础，为症状管理的生物行为方法规划和发展可持续的研究项目。 行政结构说明 这个新中心的结构不断演变，以显示我们工作的复杂性和科学重点的增加。CEBASM的行政结构如图1所示。该中心将通过实施五个资助的研究项目，并通过其生物行为科学（BSC），生物行为测量（BSM）和数据服务和分析（DSA）的核心工作来实现其目标。该中心将通过指导，培训和研究经验提高项目总监（PD）在生物行为临床研究方面的专业知识，并将帮助开发中心和其他VCU研究人员在生物行为临床研究方面的专业知识，重点是症状管理，重点是疲劳。该中心还将制定战略，以加快将研究成果传播到跨学科科学文献中，包括推进转化为实践。将使用全面的评估计划对中心活动进行评估，该计划包括可衡量的目标以及总结性和形成性评估。

The proposed P30 Center of Excellence for Biobehavioral Approaches to Symptom Management (CEBASM) builds on our successful P20 Exploratory Center for Biobehavioral Clinical Research (CBCR, P20 NR008988, McCain, PI). The CEBASM will take advantage of the synergy developed via the CBCR related to symptom management and biobehavioral outcomes as well as resources garnered and systems developed for that Center and expand them to advanced application of biobehavioral models, methods, and analyses aimed at understanding biobehavioral mechanisms, interventions, and outcomes related to symptom management with a focus on fatigue. The research base for this center of excellence is provided by Drs. Pickler, Grap, Lyon, McCain, Munro, and Elswick who collectively and in their own work have significantly advanced biobehavioral science and/or symptom management in preterm infants, patients with cancer, and in the critically ill. This group of senior investigators provided the scientific and administrative foundation for the successful P20 Center. Their expertise has guided the projects proposed here and will be instrumental in developing future biobehavioral scientists who focus on symptom management. The specific aims of the proposed P30 Center of Excellence are to 1. Expand biobehavioral research capacity for scientists conducting nursing research by centralizing research resources and infrastructure for biobehavioral clinical research focused on symptom management; 2. Advance biobehavioral approaches for symptom management, including fatigue and its associated symptoms, in diverse populations; 3. Facilitate the development and expansion of biobehavioral programs of independent, investigator initiated biobehavioral research that have a common theme of fatigue; 4. Establish a mature environment of sustainable biobehavioral research in symptom management that is clinically focused and interdisciplinary in nature. The aims of the proposed P30 Center of Excellence are relevant to several areas of opportunity identified in NINR's Strategic Plan including: 1) developing or improving biobehavioral methods, measures, and intervention strategies associated with symptom clusters; 2) developing technologies to facilitate early detection of symptoms; 3) delineating causative mechanisms underlying symptoms; 4) developing and testing interventions that improve patient response and adaptation to symptoms and symptom clusters in discrete and co-morbid conditions; 5) designing strategies to improve management of symptoms over disease trajectories; and 6) eliminating health disparities by understanding disease manifestations and testing innovative intervention in underserved populations. Further, the proposed Center will meet NINR's scientific advancement strategies of integrating biology and behavior and preparing the next generation of nurse scientists. Research emanating from the Center will delineate biobehavioral mechanisms underlying symptom management, with a focus on fatigue as a common symptom across studies and programs of biobehavioral clinical research. Center projects will address African American adolescents, adults with fatigue associated with sickle cell disease and women with breast cancer who experience fatigue and its associated constellation of symptoms that contributes to cognitive dysfunction. Research will also test biobehaviorally focused interventions to improve outcomes in pregnant African American women, women with fibromyalgia, and women with cardiovascular risk. Ultimately, Center research will lead to further interventions to improve patient outcomes related to complex constellations of symptoms, including the common symptom of fatigue. The proposed Center will: enhance research infrastructure at VCU by (a) expanding and targeting resources to promote and support research focused on the biobehavioral mechanisms, management, and outcomes of complex constellations of symptoms, including the commonly occurring symptom of fatigue; (b) expanding the biobehavioral understanding of symptom constellations in persons from diverse populations; (c) increasing opportunities for beginning investigators involved in interdisciplinary research to further develop programs of research using biobehavioral models and methods; and (d) planning for and developing sustainable research programs by building an active, interdisciplinary collaborative foundation for biobehavioral approaches to symptom management. Description of Administrative Structure The structure for this new Center is evolved to show the increased complexity and scientific focus of our work. The administrative structure of the CEBASM is illustrated in Figure 1. The Center will enact its aims through the implementation of five funded research projects and through the work of its cores for Biobehavioral Science (BSC), Biobehavioral Measurement (BSM), and Data Services and Analysis (DSA). The Center will enhance the expertise of Project Directors (PDs) in biobehavioral clinical research by mentorship, training, and research experience and will help develop expertise of Center and other VCU investigators in biobehavioral clinical research focused on symptom management with a focus on fatigue. The Center will also develop strategies to speed the dissemination of research findings into interdisciplinary scientific literature, including advancement toward translation into practice. Center activities will be assessed using a thorough evaluation plan that includes measurable goals and both summative and formative evaluations.