Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
次黄嘌呤-鸟嘌呤-黄嘌呤磷酸核糖转移酶抑制剂作为治疗传染病的多功能药物
批准号：
nhmrc : 1147368
负责人：
A/Pr Lieve Naesens
金额：
$51.09万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2018
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2018-01-01 至 2020-12-31
中文摘要
翻译
由于许多治疗细菌和寄生虫感染的一线药物的耐药性增加，迫切需要开发针对这些疾病的病原体的新的药物发现渠道。该项目开创了阻止核苷酸合成的先河，开发了治疗疟疾、人类结核病、非洲昏睡病、恰加斯病和泌尿系致病性大肠杆菌感染的新药。
英文摘要
Due to the increase in resistance to many of the frontline drugs to treat bacterial and parasitic infections, there is an urgent need to develop new pipelines for drug discovery against the pathogens that are causative agents of this diseases. This project pioneers the blocking of nucleotide synthesis to develop new drug leads to treat malaria, human tuberculosis, African sleeping sickness, Chagas disease and uropathogenic E.coli infections.
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Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
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批准号：nhmrc : GNT1147368
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项目类别：Project Grants
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资助金额：$75.56万
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财政年份：2018
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负责人：A/Pr Lieve Naesens
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依托单位：
An Integrated Study of Acyclic Nucleoside Phosphonates as Antimalarial Drugs
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批准号：nhmrc : 1030353
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项目类别：Project Grants
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资助金额：$33.38万
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财政年份：2012
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负责人：A/Pr Lieve Naesens
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依托单位：
Development of purine nucleoside phosphonates as anti-malarial drugs targeting nuceloside synthesis in Plasmodium
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批准号：nhmrc : 569703
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项目类别：NHMRC Project Grants
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资助金额：$28.6万
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财政年份：2009
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负责人：A/Pr Lieve Naesens
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依托单位：
海外基金
