Training in the Molecular Biology of Neurodegeneration

描述（由申请人提供）：我们建议继续在神经退行性疾病的分子生物学非常成功的培训计划-一个致力于培养前和博士后学生的职业生涯作为独立的研究科学家在大学和健康相关的研究实验室的计划。培训师都是哈佛的教员，他们积极研究与神经退行性疾病有关的项目，重点是阿尔茨海默病和其他与衰老有关的神经退行性疾病。他们来自哈佛医学院和六家附属研究医院：贝斯以色列女执事医疗中心、布里格姆妇女医院、儿童医院、达纳法伯癌症研究所、马萨诸塞州总医院和姆克林医院。带来了广泛的经验和实验方法，以年龄相关的神经退行性疾病的问题，该计划的教师包括分子生物学家，遗传学家，细胞生物学家，神经病理学家和生物化学家。 博士预科生是从哈佛医学院授予学位的神经科学项目的研究生中招募和抽取的。博士后学生从该计划的个别教师提名的申请人中选择。受训人员的甄选是通过培训补助金咨询委员会调解的竞争过程进行的。共有6名博士前学员和8名博士后学员提出了一个初级培训教师的28个人在年龄相关的神经退行性变的基础和应用研究的经验。在所有情况下，成功候选人的主要标准是对衰老和神经退行性疾病研究的奉献精神和兴趣，以及在以前的培训中取得的最高水平的学术成就。学生必须参加特殊的神经变性课程，研讨会，期刊俱乐部和研讨会。密切监测学生的进步和职业咨询为整个培训过程提供了一个有效的结构。该计划的目的是创建一个框架，在该框架内，未来的研究人员致力于衰老和神经退行性疾病问题的最佳培训可以发生，并且该计划教师之间已经广泛的协作互动可以在各个层面传播，从学生到教授。 公共卫生相关性：老年人中阿尔茨海默病和其他神经退行性疾病的流行率的爆炸性增加是二十一世纪的重大医学挑战之一。神经退行性疾病分子生物学培训计划提供了一个框架，在这个框架内，可以对未来致力于治疗神经退行性疾病的研究人员进行最好的培训。该计划利用了哈佛医学院及其附属医院在这一领域的广泛和集中的努力，并成功地培训了一些在神经退行性疾病研究前沿工作的领先研究科学家。

DESCRIPTION (provided by applicant): We propose to continue a highly successful Training Program in the Molecular Biology of Neurodegeneration - a program devoted to the training of pre- and postdoctoral students for careers as independent research scientists in universities and health-related research laboratories. The trainers are all Harvard faculty members with active research programs related to neurodegeneration, with an emphasis on Alzheimer's disease and other neurodegenerative disorders related to aging. They are drawn from the Harvard Medical School and six affiliated research hospitals: Beth Israel-Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, and McLean Hospital. Bringing a wide range of experience and experimental approaches to the problems of age-related neurodegeneration, the Program faculty includes molecular biologists, geneticists, cell biologists, neuropathologists, and biochemists. The predoctoral students are recruited into and drawn from the graduate students in the degree-granting Neuroscience Program of the Harvard Medical School. The postdoctoral students are chosen from among applicants nominated by individual faculty members of the Program. Selection of trainees occurs through a competitive process mediated by a Training Grant Advisory Committee. A total of six predoctoral trainees and eight postdoctoral trainees are proposed for a primary training faculty of 28 individuals experienced in basic and applied studies of age-related neurodegeneration. In all cases, the main criteria for successful candidates is dedication and interest in aging and neurodegeneration research and the highest level of academic achievement in their previous training. Students are required to participate in special neurodegeneration courses, seminars, journal clubs and symposia. Close monitoring of student progress and career advising provide an effective structure for the entire training process. The purpose of the Program is to create a framework within which the best training of future researchers devoted to problems in aging and neurodegeneration can take place, and the already extensive collaborative interactions among the Program faculty can be propagated at all levels, from student to Professor. PUBLIC HEALTH RELEVANCE: The explosive increase in the prevalence of Alzheimer's disease and other neurodegenerative disorders in the aging population is one of the great medical challenges of the twenty-first century. The Training Program in the Molecular Biology of Neurodegeneration provides a framework within which the best training of future researchers devoted to curing neurodegenerative diseases can take place. The Program capitalizes on the extensive and concentrated effort in this area taking place at Harvard Medical School and its affiliated hospitals, and has succeeded in training some of the leading research scientists working at the frontiers of neurodegenerative disease research.