Quantum Dot Sensors for Superfund Priority Substances

描述（由申请人提供）：该项目的主要目的是获得一种新的基于纳米技术的传感器材料的概念验证，用于快速和灵敏的多环芳烃（PAH）和多氯联苯（PCB）的荧光检测。这些有毒物质在ATSDR物质优先清单中排名靠前，并污染了许多美国超级基金优先场所，因此，检测和量化这些有毒物质的简单、廉价和安全的方法备受追捧。使用敏感和特异性荧光探针的基于发射的方法提供了改进的方法来做到这一点。我们的计划将创建新的化学传感器，用于检测和量化多环芳烃和多氯联苯，包括现场快速定性分析的土壤和水的污染场地，并作为分析探针的荧光光谱定量这些高级毒素。在该项目的第一阶段，我们将进行概念验证研究，以合成新的传感器探针，并验证其在受到多环芳烃和多氯联苯分析物挑战时的发射特性。新的传感器材料将作为快速和灵敏的探针，用于监测受污染的超级基金场地的有害物质的分析测试和测定。

DESCRIPTION (provided by applicant): The principal aim of this project is to obtain proof-of-concept for a new nanotechnology-based sensor material for rapid and sensitive fluorescence detection of polycyclic aromatic hydrocarbons (PAHs) and polychloro biphenyls (PCBs). Simple, cheap and safe methods to detect and quantify these toxic substances, which rank high in the ATSDR Substance Priority List and contaminate many US Superfund priority sites, are highly sought after. Emission-based methods using sensitive and specific fluorescent probes offer improved means to do this. Our plan will create new chemosensors useful for detecting and quantifying PAHs and PCBs, including on-site rapid qualitative assays of soil and water of contaminated sites and as analytical probes for the spectrofluorometric quantitization of these high-ranking toxins. In Phase I of this project we will conduct a proof-of-concept study to synthesize new sensor probes and validate their emission properties when challenged with PAH and PCB analytes. The new sensor materials will be useful as rapid and sensitive probes in analytical tests and assays for monitoring the hazardous substances at contaminated Superfund sites.