Administrative Core

损害分析/生物统计核心已被三个项目中的每一个项目广泛使用 动脉粥样硬化研究的设计和评估(参考文献1-6，以及 具体项目)。核心确保对动脉粥样硬化进行一致的定量和定性评估 损伤，充分的动力实验设计和适当的实验结果分析。特定的 服务包括A)动脉粥样硬化病变的量化；B)病变成分的定性评估；C) 细胞凋亡和原位泡腾试验；D)细胞黏附和炎症标志物；E)激光捕获 用于细胞特异性定量基因表达分析的显微解剖(LCM)；以及F)生物统计支持 包括功率计算。

The Lesion Analysis/ Biostatistics Core has been widely used by each of the three projects in the design and assessment of atherosclerosis studies (refs 1-6, and submitted manuscripts described within specific projects). The Core ensures consistent quantitative and qualitative assessment of atherosclerotic lesions, adequately powered experimental design and appropriate analysis of experimental results. Specific services include A) quantification of atherosclerotic lesions; B) qualitative assessment of lesion composition; C) apoptosis and in situ efferocytosis assays; D) markers of cell adhesion and inflammation; E) laser-capture microdissection (LCM) for cell-specific quantitative gene expression analyses; and F) biostatisticai support including power calculations.